PMID: 8602998Feb 1, 1996Paper

Myelodysplastic syndromes in childhood: report of 49 patients from a French multicentre study. French Society of Paediatric Haematology and Immunology

British Journal of Haematology
B Bader-MeunierA M Manel

Abstract

We describe the clinical, cytological and cytogenetic features of 49 cases of myelodysplastic syndromes (MDS) in childhood. Three children had received prior cytotoxic treatment (group 1); all of these had cytogenetic abnormalities and died shortly after diagnosis. 22 children had constitutional anomalies (group 2). The remaining 24 MDS were considered as 'primary' (group 3). Hypoplastic marrow was found in nine cases, and only 53% of the MDS fitted the adult FAB classification. Transformation to AML occurred in 11 cases, development of aplastic anaemia in three cases, and spontaneous remission in one case each of RA and RAEB. Differences were observed between groups 2 and 3 in terms of mean age at diagnosis (11.1 months v 5 years), rate of cytogenetic anomalies (15% v 38%) and rate of progression towards acute leukaemia (13% v 29%). In group 2, all the fur girls studied exhibited a polyclonal pattern of X-inactivation, which suggests that MDS may be only the haematological expression of an embryological defect with different target tissues. This study suggests that some MDS in childhood can exhibit particular features such as congenital anomalies associated with MDS, bone marrow hypoplasia, polyclonality, and spontaneous remis...Continue Reading

Citations

May 3, 2005·Leukemia Research·M TsurusawaUNKNOWN MDS committee of the Japanese Society of Pediatric Hematology
Dec 23, 2003·Leukemia Research·Masayuki NagasawaShuki Mizutani
Aug 26, 1998·Leukemia Research·M CetinS Göğüş
May 26, 1999·The New England Journal of Medicine·M L Heaney, D W Golde
Jul 14, 1998·Blood Reviews·A Mijović, G J Mufti
Oct 30, 2001·Leukemia·H SasakiUNKNOWN MDS Committee of the Japanese Society of Pediatric Hematology, Japan
May 16, 2003·American Journal of Medical Genetics. Part a·Anjali SharathkumarYigal Dror
Mar 26, 2003·Medical and Pediatric Oncology·Mizue OrimotoTakeshi Asano
Mar 3, 1998·American Journal of Medical Genetics·J H LinK H Lin
Mar 14, 2013·Annals of Laboratory Medicine·Young Rae KohEun Yup Lee
Oct 9, 2007·Journal of Pediatric Hematology/oncology·Ruchika GoelSameer Bakhshi
Aug 30, 2008·Pediatric Hematology and Oncology·Sevgi YetginDuygu Uçkan Cetinkaya
Oct 31, 2001·Clinical and Laboratory Haematology·H AcarD A Largaespada
Apr 17, 1998·Journal of Pediatric Hematology/oncology·E S GussetisS Graphakos
May 6, 2004·Journal of Pediatric Hematology/oncology·Tansu SipahiBetul Tavil
Mar 3, 1998·Journal of Pediatric Hematology/oncology·J Y ChuD E DeMello
Jul 17, 1999·Pediatric Hematology and Oncology·F Miélot
Oct 16, 1999·British Journal of Haematology·H HasleK R Schultz
Sep 8, 2010·Journal of Pediatric Hematology/oncology·Arzu AkyayNuket Yürür-Kutlay
Sep 28, 2014·International Journal of Hematology·Koichi MoriwakiYasuhide Hayashi
Jun 20, 2020·Annals of Hematology·Filipe MartinsSabine Blum
Aug 1, 1997·Disease-a-month : DM·P Jacobs
Jul 27, 2021·Clinics in Laboratory Medicine·Sanjay S Patel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.