Myeloid - derived suppressor cells in Type 1 diabetes are an expanded population exhibiting diverse T-cell suppressor mechanisms

PloS One
Anna GrohováLenka Palová-Jelínková

Abstract

Myeloid-derived suppressor cells (MDSC) represent a heterogeneous group of immature myeloid cells with immunoregulatory function in cancer and autoimmune diseases. In humans, two subsets of MDSC were determined based on the characteristic surface markers, monocytic MDSC (M-MDSC) and granulocytic MDSC (G-MDSC). Expansion of MDSC has been reported in some murine models and patients with autoimmune diseases and their immune-suppressive properties were characterized. However, the exact role of MDSC in the pathogenesis of autoimmune diseases is more complex and/or controversial. In type 1 diabetes mellitus (T1D), the increased frequency of MDSC was found in the blood of T1D patients but their suppressor capacity was diminished. In our study, we assessed the role of M-MDSC in the pathogenesis of T1D and showed for the first time the increased frequency of M-MDSC not only in the blood of T1D patients but also in their at-risk relatives compared to healthy donors. T1D patients with inadequate long term metabolic control showed an elevation of M-MDSC compared to patients with better disease control. Furthermore, we described the positive correlation between the percentage of M-MDSC and Th17 cells and IFN-γ producing T cells in T1D patie...Continue Reading

References

Feb 1, 1991·The Journal of Clinical Investigation·I L CampbellL C Harrison
Apr 16, 2002·The Journal of Biological Chemistry·Paulo C RodriguezAugusto C Ochoa
Mar 16, 2004·Pediatric Diabetes·O CinekK S Ronningen
Aug 2, 2005·Nature Reviews. Immunology·Vincenzo Bronte, Paola Zanovello
Jan 11, 2007·Cancer Research·Dmitry I GabrilovichHans Schreiber
Oct 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rachid MarhabaMargot Zöller
Sep 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pratima SinhaGeetha Srikrishna
Jan 6, 2009·Biochimica Et Biophysica Acta·Estelle LeclercClaus W Heizmann
Jan 9, 2009·Clinical and Experimental Immunology·A WillcoxN G Morgan
Feb 7, 2009·Nature Reviews. Immunology·Dmitry I Gabrilovich, Srinivas Nagaraj
Mar 25, 2009·Journal of Immunotherapy·Vincenzo Bronte, Simone Mocellin
Apr 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cesar A CorzoDmitry I Gabrilovich
May 12, 2009·Nature Genetics·Jeffrey C BarrettUNKNOWN Type 1 Diabetes Genetics Consortium
Feb 2, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Donggou HeHui Xu
Aug 31, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·James G CrippsJames D Gorham
Oct 20, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bingjiao YinPing-Ying Pan
Nov 27, 2010·European Journal of Immunology·Alberto Mantovani
Jul 28, 2011·Current Diabetes Reports·Peter R Baker, Andrea K Steck
Dec 6, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Changyun HuLi Wen
Jan 3, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marianna IoannouPanayotis Verginis
Mar 13, 2012·Cancer Discovery·Sergey V NovitskiyHarold L Moses
Jul 17, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Barbara ÉrsekGyörgy Nagy
Oct 5, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Huanfa YiXiang-Yang Wang
Oct 16, 2012·The Journal of Clinical Investigation·Xueqiang ZhaoZhihai Qin
Jun 26, 2013·The Journal of Experimental Medicine·Nataša ObermajerPawel Kalinski
Jun 28, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wataru FujiiYutaka Kawahito
Jan 29, 2014·Nature Reviews. Endocrinology·Bart O Roep, Timothy I M Tree
Feb 6, 2014·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Xiao-Qun HanHua-Fen Yang
Apr 29, 2014·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Fatima Whitfield-LarryMaureen A Su
Nov 6, 2014·Annals of the Rheumatic Diseases·Chunqing GuoXiang-Yang Wang
Nov 27, 2014·Cytometry. Part B, Clinical Cytometry·Vera DamuzzoSusanna Mandruzzato

❮ Previous
Next ❯

Citations

Apr 27, 2021·Journal of Autoimmunity·Glenn F van WigcherenGeorgina Flórez-Grau

❮ Previous
Next ❯

Methods Mentioned

BETA
blood
PMA
flow cytometry
ELISA

Software Mentioned

FlowJo
GraphPad Prism

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.