Myeloid cell heterogeneity in cancer: not a single cell alike

Cellular Immunology
Mate KissDamya Laoui

Abstract

Tumors of various histological origins show abundant infiltration of myeloid cells from early stages of disease progression. These cells have a profound impact on antitumor immunity and influence fundamental processes that underlie malignancy, including neoangiogenesis, sustained cancer cell proliferation, metastasis and therapy resistance. For these reasons, development of therapeutic approaches to deplete or reprogram myeloid cells in cancer is an emerging field of interest. However, knowledge about the heterogeneity of myeloid cells in tumors and their variability between patients and disease stages is still limited. In this review, we summarize the most recent advances in our understanding about how the phenotype of tumor-associated macrophages, monocytes, neutrophils, myeloid-derived suppressor cells and dendritic cells is dictated by their ontogeny, activation status and localization. We also outline major open questions that will only be resolved by applying high-dimensional single-cell technologies and systems biology approaches in the analysis of the tumor microenvironment.

Citations

Jul 25, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dimitra KerdidaniMaria Tsoumakidou
Aug 31, 2018·International Journal of Molecular Sciences·Benjamin W JohnsonAli S Arbab
Aug 8, 2019·Angewandte Chemie·Yizhe ZhangAmy E Herr
Jun 20, 2019·Frontiers in Immunology·Marie LavironAlexandre Boissonnas
Oct 11, 2019·The Journal of Clinical Investigation·Karim MahiddineAdrian Erlebacher
Feb 23, 2020·The Journal of Pathology·Tim Beltraminelli, Michele De Palma
Mar 15, 2020·Journal for Immunotherapy of Cancer·Lihong Wang-BishopJohn T Wilson
Aug 4, 2019·The Journal of Experimental Medicine·Anders EtzerodtToby Lawrence
Jul 14, 2018·Cancer Immunology, Immunotherapy : CII·Viktor UmanskyZvi G Fridlender
Mar 7, 2019·Scientific Reports·Michelle R GoulartOliver A Garden
Jan 30, 2019·Nature Reviews. Nephrology·Patrick Ming-Kuen TangHui-Yao Lan
Oct 28, 2019·Oncoimmunology·Jenny SprootenAbhishek D Garg
Nov 7, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·An CoosemansDirk Timmerman
Jul 12, 2020·International Journal of Molecular Sciences·Greta CapraraMarco Erreni
Aug 25, 2018·Cellular and Molecular Life Sciences : CMLS·Natalia Arenas-RamirezOnur Boyman
Jun 24, 2018·Cancer Metastasis Reviews·Jennifer K ColbyImad Shureiqi
Dec 15, 2018·Journal of Leukocyte Biology·Shuvasree SenGuptaCarole A Parent
Aug 1, 2020·Frontiers in Immunology·Els LebeggeJo A Van Ginderachter
Oct 24, 2018·Frontiers in Immunology·Emile J ClappaertDamya Laoui
Jun 21, 2019·International Journal of Molecular Sciences·Loredana AlboniciRoberto Bei
Jun 5, 2020·The Journal of Clinical Investigation·Chong WuLimin Zheng
Mar 11, 2020·Nature Reviews. Clinical Oncology·Álvaro Quintanal-VillalongaCharles M Rudin
Dec 19, 2019·Frontiers in Immunology·Lisa Haas, Anna C Obenauf
Aug 24, 2019·Journal for Immunotherapy of Cancer·Arsen OsipovAdrian G Murphy
Sep 25, 2020·Journal of Leukocyte Biology·Wang LongHelong Dai
May 29, 2018·Cancer Metastasis Reviews·Andreas WeigertBernhard Brüne
Aug 23, 2020·International Journal of Molecular Sciences·Augusto BleveFrancesca Maria Consonni
Oct 13, 2020·Frontiers in Oncology·Máté KissDamya Laoui
Nov 25, 2020·Proceedings of the National Academy of Sciences of the United States of America·Silke EisingerMikael C I Karlsson
Nov 6, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Vincent BernardHector A Alvarez
Sep 13, 2018·Cancer Research·Ming YangClaire E Lewis
Jan 22, 2021·Cellular & Molecular Immunology·Alberto MantovaniPaola Allavena

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Shanshan WanTheodore H Welling
Frontiers in Bioscience (Scholar Edition)
Koji FukudaKounosuke Watabe
International Immunopharmacology
Satoshi UehaKouji Matsushima
© 2022 Meta ULC. All rights reserved