Myeloid cell leukemia-1 dependence in acute myeloid leukemia: a novel approach to patient therapy

Oncotarget
Tapan Mahendra KadiaMarina Konopleva

Abstract

Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults, affecting approximately 21,000 people annually (nearly 11,000 deaths) in the United States. B-cell lymphoma 2 (BCL-2) family proteins, notably myeloid cell leukemia-1 (MCL-1), have been associated with both the development and persistence of AML. MCL-1 is one of the predominant BCL-2 family members expressed in samples from patients with untreated AML. MCL-1 is a critical cell survival factor for cancer and contributes to chemotherapy resistance by directly affecting cell death pathways. Here, we review the role of MCL-1 in AML and the mechanisms by which the potent cyclin-dependent kinase 9 inhibitor alvocidib, through regulation of MCL-1, may serve as a rational therapeutic approach against the disease.

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Jan 8, 2020·Cell Death and Differentiation·Viacheslav V SenichkinGelina S Kopeina
Feb 6, 2020·Cancer Discovery·Nicholas J ShortNaval Daver
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Jul 25, 2021·International Journal of Molecular Sciences·Alvina I KhamidullinaAlexandra V Bruter

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Methods Mentioned

BETA
ubiquitination

Clinical Trials Mentioned

NCT02520011
NCT02675452
NCT03218683
NCT02992483
NCT02979366

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