Myeloid dendritic cells are decreased in peripheral blood of Alzheimer's disease patients in association with disease progression and severity of depressive symptoms

Journal of Neuroinflammation
Antonio CiaramellaPaola Bossù

Abstract

Dendritic cells (DCs) are major orchestrators of immune responses and inflammation. They are migratory cells, which may play a role in Alzheimer's disease (AD), as suggested by prior in vitro studies. With the intent to investigate the clinical relevance of DC modifications in vivo, the present study was aimed to evaluate the levels of blood DCs in AD patients, in relation to the progression of the disease, the severity of its symptoms, and the treatment with acetylcholinesterase inhibitors (AChEIs), a class of drugs used to improve cognitive functioning in people with dementia. The two main subpopulations of immature blood DCs, namely myeloid (mDCs) and plasmacytoid (pDCs) cells, were evaluated by flow cytometry analysis in 106 AD patients, in comparison with the same cells from 65 individuals with mild cognitive impairment (MCI) and 73 healthy control subjects (HC). The relationship between blood DC levels and symptom severity was also assessed in AD patients, and their blood DC frequency was considered both in the absence or presence of treatment with AChEIs. A significant depletion in blood mDCs was observed in AD patients, as compared to HC and MCI subjects. At variance, pDC levels were comparable among the three groups of...Continue Reading

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Citations

Mar 6, 2017·Alzheimer's Research & Therapy·Róisín M McManus, Michael T Heneka
Nov 1, 2018·Journal of Molecular Neuroscience : MN·Pritha GuptaTusharkanti Ghosh
Jun 5, 2017·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Monica PinoliMarco Cosentino
Aug 18, 2018·Alzheimer's Research & Therapy·Sudhanshu AgrawalAnshu Agrawal
Mar 18, 2019·Clinical and Experimental Nephrology·Masato IkedaTakashi Yokoo
May 21, 2018·Cellular and Molecular Life Sciences : CMLS·Antero SalminenAnu Kauppinen
Jun 28, 2018·Cellular and Molecular Neurobiology·Veronika BrezovakovaSantosh Jadhav
Jan 6, 2021·Cell Biochemistry and Function·Victoria StiglbauerStefan M Gold
Mar 2, 2021·Journal of Alzheimer's Disease : JAD·Guimei ZhangLi Sun
Nov 7, 2018·Molecular Immunology·Mary Beth YuWilliam H R Langridge
Apr 29, 2021·Behavioural Brain Research·Paul J FitzgeraldBrendon O Watson
Jun 17, 2020·Dementia and Geriatric Cognitive Disorders·Sai Batchu

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Methods Mentioned

BETA
blood drawn
flow cytometry
blood draws
FACS

Software Mentioned

Prism
CellQuest
BDCA
GraphPad

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