Myeloid-derived suppressor cells contribute to bone erosion in collagen-induced arthritis by differentiating to osteoclasts

Journal of Autoimmunity
Hui ZhangShu Man Fu

Abstract

Bone erosion is a sign of severe rheumatoid arthritis and osteoclasts play a major role in the bone resorption. Recently, myeloid-derived suppressor cells (MDSC) has been reported to be increased in collagen-induced arthritis (CIA). The number of circulating MDSCs is shown to correlate with rheumatoid arthritis. These findings suggest that MDSCs are precursor cells involved in bone erosion. In this study, MDSCs isolated from mice with CIA stimulated with M-CSF and RANKL in vitro expressed osteoclast markers and acquired osteoclast bone resorption function. MDSCs sorted from CIA mice were transferred into the tibia of normal DBA/1J mice and bones were subjected to histological and Micro CT analyses. The transferred CIA-MDSCs were shown to differentiate into TRAP(+) osteoclasts that were capable of bone resorption in vivo. MDSCs isolated from normal mice had more potent suppressor activity and much less capability to differentiate to osteoclast. Additional experiments showed that NF-κB inhibitor Bay 11-7082 or IκB inhibitor peptide blocked the differentiation of MDSCs to osteoclast and bone resorption. IL-1Ra also blocked this differentiation. In contrast, the addition of IL-1α further enhanced osteoclast differentiation and bone...Continue Reading

References

Aug 26, 2000·Cytokine & Growth Factor Reviews·A DenkB Baumann
Sep 1, 2000·Science·G A Rodan, T J Martin
Jun 8, 2002·Science·Sabine StollRonald N Germain
Oct 16, 2002·Annals of the Rheumatic Diseases·E M Gravallese
May 16, 2003·Nature·William J BoyleDavid L Lacey
May 16, 2003·Nature·Gary S Firestein
Jan 30, 2004·Cytokine & Growth Factor Reviews·Steeve Kwan TatYannick Fortun
Mar 23, 2006·Annual Review of Immunology·Matthew C WalshYongwon Choi
Feb 7, 2009·Nature Reviews. Immunology·Dmitry I Gabrilovich, Srinivas Nagaraj
Jan 28, 2010·Arthritis Research & Therapy·Yahui Grace ChiuChristopher T Ritchlin
Feb 23, 2010·Current Opinion in Immunology·Elisa PeranzoniVincenzo Bronte
Jun 12, 2013·Arthritis and Rheumatism·Abhishek TrigunaiteTrine N Jørgensen
Feb 15, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Hui ZhangShu Man Fu

❮ Previous
Next ❯

Citations

Oct 4, 2016·Medical Hypotheses·Omar Valero-MonroyNicolas Serafin-Higuera
Apr 25, 2018·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Andrea ManciniClaudio Festuccia
Sep 22, 2018·Inflammation and Regeneration·Sho SendoAkio Morinobu
Dec 20, 2018·Frontiers in Immunology·Min LiShengjun Wang
Mar 11, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Dan LiuGuoqing Li
May 28, 2019·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Antero SalminenKai Kaarniranta
Aug 17, 2019·Disease Models & Mechanisms·Stephanie YoungAndrew W B Craig
May 28, 2019·Frontiers in Immunology·Francesca Maria ConsonniAntonio Sica
Oct 27, 2015·Clinical Reviews in Allergy & Immunology·Nicole J Horwood
Mar 16, 2019·Frontiers in Immunology·Irene T SchrijverThierry Roger
Oct 8, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Antero Salminen
Jan 23, 2021·Life Sciences·Jamshid Gholizadeh NavashenaqAmirhossein Sahebkar
Jan 12, 2021·Frontiers in Immunology·Surabhi SurabhiNikolai Siemens
Dec 29, 2020·Seminars in Thrombosis and Hemostasis·Hanshi Wang, Xizhuang Bai
Sep 1, 2021·Periodontology 2000·Kyu Hwan KwackKeith L Kirkwood
Oct 13, 2021·Cellular and Molecular Life Sciences : CMLS·Zhiguo LingYueqi Chen
Oct 13, 2021·Journal of Dental Research·K H KwackK L Kirkwood
Oct 19, 2021·Frontiers in Physiology·Kyu Hwan KwackKeith L Kirkwood
Nov 9, 2021·Frontiers in Immunology·Xue LiNiansheng Yang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.