Myeloid differentiation-2 is a potential biomarker for the amplification process of allergic airway sensitization in mice

Allergology International : Official Journal of the Japanese Society of Allergology
Daisuke KoyamaShu Hashimoto

Abstract

Allergic sensitization is a key step in the pathogenesis of asthma. However, little is known about the molecules that are critical regulators for establishing allergic sensitization of the airway. Thus, we conducted global gene expression profiling to identify candidate genes and signaling pathways involved in house dust mite (HDM)-induced allergic sensitization in the murine airway. We sensitized and challenged mice with HDM or saline as a control through the airway on days 1 and 8. We evaluated eosinophilia in bronchoalveolar lavage fluid (BALF), airway inflammation, and mucus production on days 7 and 14. We extracted total RNA from lung tissues of HDM- and saline-sensitized mice on days 7 and 14. Microarray analyses were performed to identify up-regulated genes in the lungs of HDM-sensitized mice compared to the control mice. Data analyses were performed using GeneSpring software and gene networks were generated using Ingenuity Pathways Analysis (IPA). We identified 50 HDM-mediated, stepwise up-regulated genes in response to allergic sensitization and amplification of allergic airway inflammation. The highest expressed gene was myeloid differentiation-2 (MD-2), a lipopolysaccharide (LPS)-binding component of Toll-like recept...Continue Reading

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Citations

May 18, 2016·Allergology International : Official Journal of the Japanese Society of Allergology·Yasuhiro GonShu Hashimoto
Aug 22, 2021·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Takashi IshiiNaomi Yamashita

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