PMID: 8589366Dec 1, 1995Paper

Myeloid progenitor cell regulatory effects of vascular endothelial cell growth factor

International Journal of Hematology
H E BroxmeyerD B Donner

Abstract

Vascular endothelial cell growth factor (VEGF) is a ligand for the tyrosine kinase receptor Flk-1/KDR and Flt1 and is considered to be an endothelial cell specific mitogen that plays an important role in angiogenesis. Since Flk-1 mRNA has been detected in primitive and more mature hematopoietic cells, recombinant human VEGF was evaluated for its influence on hematopoiesis, which was assayed as in vitro colony formation by myeloid progenitor cells from human bone marrow. VEGF enhanced colony formation by mature subsets of granulocyte-macrophage and erythroid progenitor cells that had been stimulated with a colony stimulating factor. In contrast, VEGF inhibited colony formation by more immature subsets of granulocyte-macrophage, erythroid and multipotential progenitor cells synergistically stimulated to proliferate with a colony stimulating factor and either steel factor or the ligand for the Flt-3 receptor tyrosine kinase. VEGF produced effects similar to those given above on purified CD34 progenitor cells from bone marrow and VEGF effects were neutralized by VEGF antibodies. However, when assessed for effects on single sorted CD34 cells, VEGF only enhanced or suppressed colony formation by granulocyte-macrophage progenitor cell...Continue Reading

Citations

May 10, 2002·International Journal of Hematology·Renchi Yang, Zhong Chao Han
Jun 5, 2003·Nature Medicine·Napoleone FerraraJennifer LeCouter
Aug 6, 2004·Endocrine Reviews·Napoleone Ferrara
Aug 9, 2005·Expert Opinion on Emerging Drugs·Philip J Nivatpumin, Steven D Gore
Sep 21, 2007·Journal of Cutaneous Pathology·Amal H A GomaaJag Bhawan
Sep 27, 2008·Cancer Gene Therapy·G J Dougherty, S T Dougherty
Sep 10, 2014·Antioxidants & Redox Signaling·Sabrina FarrokhHeiner Schaal
Feb 16, 2002·Journal of Hematotherapy & Stem Cell Research·Kyunghee Choi
Feb 1, 1997·Endocrine Reviews·N Ferrara, T Davis-Smyth
Dec 31, 2003·The Journal of Biological Chemistry·Robert WalczakPeter Tontonoz
Apr 19, 2002·The Oncologist·Alan F List
Jun 12, 2003·Annals of the New York Academy of Sciences·Shahin RafiiKoichi Hattori
Dec 10, 2008·Expert Opinion on Biological Therapy·Aravind Ramakrishnan, H Joachim Deeg
Dec 18, 2008·Annals of Medicine·Pieter W HolmRené A Tio
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·R MöhleS Rafii
Mar 22, 2007·Expert Opinion on Biological Therapy·Benjamin F JohnsonMichael A Morse
Jan 13, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Elma KurtagicMatthew A Nugent
Dec 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mikhail M DikovDavid P Carbone
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·A Mario MarcondesH Joachim Deeg
May 1, 2013·Journal of Biomedical Materials Research. Part a·Emmanuel E SadavaYuri W Novitsky
Jul 7, 2017·Cancer Metastasis Reviews·Marek Z WojtukiewiczKenneth V Honn
Jun 8, 2017·Journal of Biomedical Materials Research. Part a·Sharon L HyzyBarbara D Boyan
Jun 29, 2018·Integrative Biology : Quantitative Biosciences From Nano to Macro·Kuihua ZhanXinhong Wang
Mar 29, 2001·Journal of Hematotherapy & Stem Cell Research·B FossO Bruserud
Jun 10, 2006·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·F ZiemssenS Grisanti
Sep 18, 2020·Tissue Engineering. Part B, Reviews·Eun-Jin LeeStella Alimperti
May 12, 2021·Stem Cell Reviews and Reports·Andrea M PattersonChristie M Orschell
Feb 28, 2004·Trends in Cardiovascular Medicine·M Clauss
Jun 2, 1998·Kidney International·P Carmeliet, D Collen
Jan 27, 1998·Hematology/oncology Clinics of North America·M J Weiss
Sep 8, 1999·Science·B L ZieglerC Peschle

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