Myeloid sarcoma is associated with superior event-free survival and overall survival compared with acute myeloid leukemia

Apostolia-Maria TsimberidouElihu H Estey


It is unknown whether patients with nonleukemic myeloid sarcoma (MS) and those with acute myeloid leukemia (AML) have similar responses to anti-AML treatment. In the current study, the authors addressed this question by matching MS patients with analogous AML patients and comparing their clinical outcomes. Twenty-three consecutive patients with MS and 1720 consecutive patients with AML were identified who presented at The University of Texas M. D. Anderson Cancer Center from 1990 to 2004. All AML patients and 16 MS patients received cytarabine plus idarubicin or fludarabine as induction remission therapy. Treated MS patients and AML patients were matched according to cytogenetics, age, Zubrod performance status, and time of treatment. Event-free survival (EFS) and overall survival (OS) were compared using Kaplan-Meier analyses. Complete response rates were 69% in patients with MS and 57% in patients with AML (P = .45). The respective 2-year EFS and OS rates were 32% and 18% (P = .08) and 43% and 29% (P = .11). Matches were identified for 14 MS patients who were paired repeatedly with 91 AML patients to produce 94 matches (3 AML patients were matched twice). EFS was longer in 56 MS pair mates, shorter in 26 pair mates, and simil...Continue Reading


Apr 1, 2010·Journal of Lower Genital Tract Disease·Desiree H-A SkeeteTerence J Colgan
May 11, 2010·Internal Medicine·Darko AnticNada Kraguljac
Nov 23, 2010·Internal Medicine·Songul SerefhanogluOsman Ilhami Ozcebe
Dec 27, 2011·Neurologia Medico-chirurgica·Mineko MurakamiAkira Matsuno
Jun 21, 2011·Haematologica·Friedrich StölzelMarkus Schaich
Dec 3, 2010·Journal of Clinical and Experimental Hematopathology : JCEH·Yasuhiro YamamotoHirokazu Nakamine
Mar 28, 2013·Archives of Pathology & Laboratory Medicine·Jane ZhouL Jeffrey Medeiros
Jan 7, 2011·Case Reports in Medicine·Ibrahim ElghissassiHassan Errihani
Oct 9, 2013·Head and Neck Pathology·Jacques RaphaelVeronique Saada
Feb 8, 2014·International Journal of Hematology·Tomomi SakaiKoichi Oshima
Aug 12, 2014·Case Reports in Hematology·Pankit Vachhani, Prithviraj Bose
Oct 13, 2011·Neurocritical Care·G M MalloryG Lanzino
Nov 5, 2014·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Jan M HoracekPavel Zak
Dec 12, 2012·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Tomas KupsaLadislav Jebavy
Oct 4, 2013·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Jan M HoracekPavel Zak
Apr 16, 2014·Leukemia & Lymphoma·Mariella D'angiòAnna Maria Testi
May 12, 2015·Expert Review of Hematology·Adarsh VennepureddyTerenig Terjanian
Jul 14, 2016·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Ankur JainPankaj Malhotra
Aug 10, 2013·The American Journal of the Medical Sciences·Jingsong HeHuang He
Mar 10, 2016·International Journal of Surgery Case Reports·S N TanM Mat-Baki
Apr 6, 2013·Journal of the Chinese Medical Association : JCMA·Kai-Di MeiShih-Lun Chang
Dec 5, 2012·Seminars in Oncology·Madhava BaikaidiGloria J Morris
Dec 12, 2012·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Darko AnticDragica Tomin
Jan 18, 2016·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·S YossiA d'Hombres
Sep 20, 2012·Pathology·Georgina HodgesEdward Morris
Jul 18, 2015·American Journal of Clinical Pathology·Carla S Wilson, L Jeffrey Medeiros
Nov 24, 2011·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Esther S HongKenneth M Goins
Oct 20, 2009·Journal of the American Academy of Dermatology·Catherine M DigiorgioErin E Boh
Apr 19, 2015·World Neurosurgery·Jacob R JosephDaniel A Orringer
Jun 4, 2011·Hematological Oncology·Batia AvniOra Paltiel
Jan 3, 2013·International Journal of Cancer. Journal International Du Cancer·Maro OhanianZeev Estrov
Sep 3, 2011·International Journal of Laboratory Hematology·J M KlcoJ L Frater
Jan 23, 2013·European Journal of Haematology·Salvatore GuastafierroGiuseppe Colella
Nov 8, 2013·Case Reports in Hematology·Jeffrey W Craig, Richard J Lin
Apr 21, 2016·Blood Reviews·Melhem SolhAsad Bashey
Jun 30, 2015·Human Pathology·Beenu ThakralL Jeffrey Medeiros
Jun 2, 2011·Journal of Biomedicine & Biotechnology·Håkon ReikvamØystein Bruserud
Aug 19, 2014·Clinical Lymphoma, Myeloma & Leukemia·Maro OhanianLynne V Abruzzo
Jul 29, 2011·Blood·Richard BakstJoachim Yahalom
Jan 15, 2010·Clinical and Experimental Otorhinolaryngology·Ki-Hong ChangYong-Soo Park
Jun 15, 2016·Current Treatment Options in Oncology·Nathan GossaiBrenda Weigel
Sep 8, 2016·Journal of Oral and Maxillofacial Pathology : JOMFP·Moumita SenguptaBoby Majumdar
Aug 31, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chezi GanzelMartin S Tallman
Jun 13, 2015·International Journal of Surgical Pathology·Yongcheng Benjamin Tan
Oct 1, 2011·Therapeutic Advances in Hematology·Batia Avni, Maya Koren-Michowitz
Mar 31, 2018·Hematological Oncology·Keisuke KawamotoKoichi Ohshima
Mar 14, 2018·European Journal of Haematology·Helena ClaerhoutNancy Boeckx
Nov 21, 2017·Clinical Case Reports·Dorothy Mitkowski, Lidia Gil
Aug 12, 2014·British Journal of Hospital Medicine·Chien-Chung WangRay-Yi Chen
Aug 13, 2017·BMJ Case Reports·Branko CuglievanMichael E Rytting
Mar 1, 2018·BMC Nephrology·Liang YingShan Mou
Dec 12, 2012·British Journal of Clinical Pharmacology·Johan G C van HasseltAlwin D R Huitema
Nov 5, 2019·Pediatric Hematology and Oncology·Ting ZhouKevin E Fisher
Jan 7, 2020·Current Opinion in Hematology·Omar A Shahin, Farhad Ravandi
Aug 18, 2020·Pediatric Hematology and Oncology·Guanhua HuLe-Ping Zhang
Sep 3, 2020·Technology in Cancer Research & Treatment·Zixuan ZhaoShengming Deng
Jun 2, 2018·Case Reports in Hematology·Ryan Nguyen, Hamid Sayar
Nov 21, 2017·Internal Medicine·Kenji TokunagaYutaka Okuno
Jan 16, 2019·BMJ Case Reports·Rachna MeelSameer Bakhshi
Mar 21, 2019·Case Reports in Hematology·Karuna DewanCourtney B Shires
Jun 25, 2020·Current Oncology Reports·Richard BakstJoachim Yahalom
May 1, 2020·British Journal of Neurosurgery·Francesca Romana BarbieriPierpaolo Lunardi
Mar 19, 2020·Frontiers in Oncology·Rebecca EpperlyM Paulina Velasquez

Related Concepts

Antineoplastic Chemotherapy Protocols
Remission Induction
Idarubicin Hydrochloride
Acute Myeloid Leukemia, M1
Survival Rate
Progression-Free Survival
Granulocytic Sarcoma

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.