Myeloperoxidase, a possible biomarker for the early diagnosis of cardiac diastolic dysfunction with preserved ejection fraction

Journal of Enzyme Inhibition and Medicinal Chemistry
Bogdan Ioan CoculescuCristina Mariana Stocheci

Abstract

The current study was conducted on a sample of 91 patients diagnosed with diastolic dysfunction (DD) with preserved systolic function caused by a painful chronic ischaemic cardiopathy - angina pectoris stable at the effort. The diagnosis was established following anamnesis, electrocardiogram, and echocardiography. Myeloperoxidase (MPO) serum levels were assessed in all patients and then these values were correlated with some of the echocardiography parameters that proved the mentioned diagnosis. In conclusion, the execution of this investigation triad (electrocardiogram, echocardiography, and MPO) allows: Stratifying the patients depending on the disease risk by early detecting of any possible DD with preserved systolic function. The use of the MPO increased circulating levels as a biomarker for diagnosis and risk due to the statistically significant correlation between those and the results of the other two aforementioned paraclinical investigation.

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Citations

Mar 8, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Bogdan-Ioan CoculescuCristina Mariana Stocheci
Nov 22, 2019·Frontiers in Molecular Biosciences·Kuldeep DhamaSunil Kumar Joshi
Dec 19, 2019·Antioxidants & Redox Signaling·Chrishan J A RamachandraDerek J Hausenloy
Nov 15, 2020·Journal of Enzyme Inhibition and Medicinal Chemistry·Adriana DiaconuValeriu Gabi Dincă
Jul 3, 2021·Antioxidants·Nicoleta Bianca TudorachiElena Mihaela Cărăuşu

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