Myeloperoxidase is associated with insulin resistance and inflammation in overweight subjects with first-degree relatives with type 2 diabetes mellitus

Diabetes & Metabolism Journal
Anel Gómez GarcíaCleto Alvarez Aguilar

Abstract

Family history of type 2 diabetes mellitus (T2DM) is one of risk factors for that in future a subject can develop diabetes. Insulin resistance (IR) is important in the pathogenesis of T2DM. There is evidence that oxidative stress plays an important role in the etiology and/or progression of diabetes. Myeloperoxidase (MPO) participates in developing of inflammation. The objective was to investigate if MPO is associated with IR and inflammation in individuals with first-degree relatives of T2DM. Cross-sectional study in 84 overweight individuals with family history of T2DM divided in two groups according to IR, group with IR (homeostasis model assessment [HOMA] ≥2.5; n=43) and control group (CG; HOMA <2.5; n=41). Complete clinical history and a venous blood sample were collected for measuring glucose and lipids profile, insulin, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), MPO, glutathione reductase (GRd), glutathione peroxidase, and superoxide dismutase. MPO, TNF-α, and IL-6 were higher in patients with IR than in CG (MPO: 308.35 [190.85 to 445.42] vs. 177.35 [104.50 to 279.85], P=0.0001; TNF-α: 13.46 [10.58 to 18.88] vs. 9.39 [7.53 to 11.25], P=0.0001; IL-6: 32.93 [24.93 to 38.27] vs. 15.60 [12.93 to 26.27]; P=0.0001,...Continue Reading

References

Mar 1, 1995·Diabetes Research and Clinical Practice·B Wierusz-WysockaM Kaźmierczak
Apr 30, 1998·Current Opinion in Cell Biology·T Finkel
Oct 12, 2001·International Journal of Hematology·W M Nauseef
Nov 22, 2001·JAMA : the Journal of the American Medical Association·R ZhangS L Hazen
Jan 16, 2002·JAMA : the Journal of the American Medical Association·Earl S FordWilliam H Dietz
May 16, 2003·JAMA : the Journal of the American Medical Association·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Sep 4, 2003·Circulation·Stephan BaldusUNKNOWN CAPTURE Investigators
Sep 16, 2003·Obesity Research·Lais U MonzilloChristos S Mantzoros
Sep 15, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·E PihlM Zilmer
Nov 1, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·V F XimenesI L Brunetti
Aug 8, 2008·Primary Care Diabetes·Carlos KornhauserKazimierz Wrobel
Oct 15, 2008·Salud pública de México·Catarina Munguía-MirandaMiguel Cruz-López
Jul 23, 2009·Antioxidants & Redox Signaling·Betty S van der VeenPeter Heeringa
Jul 14, 2010·Antioxidants & Redox Signaling·Xin Gen Lei, Marko Z Vatamaniuk
Apr 8, 2011·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·A ZengiG Ozgen
Jan 26, 2012·Indian Journal of Endocrinology and Metabolism·Edavan P PraveenAriachery C Ammini
Dec 21, 2013·Diabetes Care·UNKNOWN American Diabetes Association
Jan 1, 1998·Journal of the American Oil Chemists' Society·Okezie I Aruoma

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Citations

Jun 10, 2016·Journal of Psychiatric Research·Rodrigo B MansurElisa Brietzke
Feb 7, 2018·Journal of Diabetes Research·Tingfu DuKaili Ma
Aug 9, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kyle J PrestonRosario Scalia
Jul 30, 2018·Molecular Biology Reports·Mohammad AliSubrata K Biswas
Jan 29, 2020·Antioxidants & Redox Signaling·Michael J Davies, Clare L Hawkins
Aug 15, 2020·Frontiers in Immunology·Gholamreza DaryaborKurosh Kalantar
Feb 6, 2017·Indian Journal of Clinical Biochemistry : IJCB·Ashish AgarwalRukmini Mysore Srikantiah
Apr 12, 2020·Scientific Reports·Mohammad G QaddoumiJehad Abubaker
Aug 15, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Lu PengHuina Zhang

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BETA
GTPases

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SPSS

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