Myeloperoxidase polymorphism and cognitive decline in older adults in the Health, Aging, and Body Composition Study

American Journal of Epidemiology
Sandra K PopeTamara Harris

Abstract

Myeloperoxidase, an antimicrobial enzyme, produces oxidative free radicals. Rarely found in normal brain tissue, myeloperoxidase has been detected in microglia associated with Alzheimer's disease plaques. The authors examined a G-463A polymorphism in the promoter region of the myeloperoxidase gene (MPO) to determine the relation of MPO variants to cognitive decline over 4 years in a cohort of adults, aged 70-79 years at baseline (1997-1998), recruited from Memphis, Tennessee, and Pittsburgh, Pennsylvania, into the Health, Aging, and Body Composition Study. In this sample, 8% of the participants had the AA, 36.9% the AG, and 55.2% the GG genotype of MPO. The frequency of AA and AG genotypes was higher in Blacks than Whites (11.2% vs. 5.9%, and 44.1% vs. 32.9%, respectively). Multivariate logistic regression analyses showed that, for participants with the MPO AA genotype, cognitive decline was 1.58 (95% confidence interval: 1.07, 2.35) times more likely than for participants with the AG genotype and 1.96 (95% confidence interval: 1.33, 2.88) times more likely than for those with the GG genotype. Interactions between MPO and race, sex, or the apolipoprotein gene were not significant. In this sample, MPO AA, associated with decreas...Continue Reading

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Citations

Jan 25, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Monika TalarowskaPiotr Gałecki
Feb 15, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Shun-Fa YangPo-Hui Wang
Jun 17, 2008·Free Radical Biology & Medicine·Doris L Lefkowitz, Stanley S Lefkowitz
Feb 7, 2013·Blood Pressure·Yi-Chien LiuYu-Mei Hsueh
Jul 20, 2014·Advances in Medical Sciences·Monika TalarowskaPiotr Gałecki
Jun 28, 2016·Neuroscience and Biobehavioral Reviews·R S Ray, Anju Katyal
Oct 1, 2010·Acta Neuropsychiatrica·Piotr GałeckiJanusz Szemraj
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