Myelophil, a mixture of Astragali Radix and Salviae Radix extract, moderates toxic side effects of fluorouracil in mice.

World Journal of Gastroenterology : WJG
Jang Woo ShinChang Gue Son

Abstract

To evaluate the efficacy of Myelophil, an extract containing Astragali Radix and Salviae Radix, for reducing complications induced by 5-fluorouracil (5-FU) in a gastrointestinal cancer model. We injected 5-FU into mice and then administered Myelophil to examine the ability of the drug to treat the side effects of 5-FU in mice. Peripheral blood counts, histological examinations, and colony-forming assays of bone marrow were conducted, followed by swimming tests and assessment of survival times. Myelophil restored red and white blood cells and platelets in blood, and recovered cell density in bone marrow to levels comparable to those observed within the control group. In addition, Myelophil significantly increased colony-forming unit granulocyte-macrophage (CFU-GM) and CFU-erythroid (CFU-E) compared to the control group. We confirmed that interleukin-3 gene expression was upregulated by Myelophil in spleen cells. Myelophil administration also doubled the survival rate of mice that were severely myelosuppressed as a result of 5-FU injection at a lethal dose of 70%. Finally, the swimming performance of mice significantly improved as a result of Myelophil treatment. These results provide experimental evidence in support of clinical ...Continue Reading

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Citations

Jul 21, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jin-Seok LeeChang-Gue Son
Aug 16, 2016·Frontiers in Pharmacology·Katrin M HoffmannGünter Gisselmann
Aug 11, 2017·BMC Complementary and Alternative Medicine·Jinhee KimNo Soo Kim
Aug 27, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J M BakerGianni Parise

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