Abstract
Soft agar culture studies of 43 immunologically characterized patients with childhood acute lymphocytic leukemias (ALL) are presented. The immunologic subsets studied include "null"-cell, pre-B-cell, and T-cell leukemias. Abnormal myelopoiesis, including high peripheral blood and low marrow, colony-forming cell numbers, low colony-stimulating activity, and normal maturation of colony-forming cells in vitro was noted in each group as previously described for immunologically uncharacterized ALL. We conclude that immunologic subsets of childhood lymphoblastic leukemia cause similar abnormalities of myelopoiesis. Lack of differences in growth characteristics among immunologic subsets of ALL make it impossible to use this tissue culture technique in subclassification of these leukemic disorders.
References
Nov 1, 1977·Clinical Immunology and Immunopathology·C M BalchA R Lawton
Dec 24, 1977·Lancet·J M ChessellsM F Greaves
Apr 20, 1978·The New England Journal of Medicine·L B VoglerM D Cooper
Jun 1, 1977·The Journal of Surgical Research·C M BalchL B Vogler
Mar 1, 1978·Mutation Research·D Viceps-Madore, L Mezger-Freed
May 1, 1975·The Journal of Experimental Medicine·G D Ross, M J Polley
Sep 1, 1975·The Journal of Pediatrics·A H RagabS C Duck
May 1, 1976·The Journal of Pediatrics·A H RagabE Phelan
Oct 9, 1971·Lancet·M D CooperD E Bockman
Aug 1, 1972·The Journal of Experimental Medicine·M JondalH Wigzell
Jun 1, 1966·The Australian Journal of Experimental Biology and Medical Science·T R Bradley, D Metcalf
Mar 1, 1974·Cancer·A H RagabM L Myers
Jan 1, 1974·Annual Review of Medicine·P L Greenberg, S L Schrier
Jun 3, 1971·The New England Journal of Medicine·P L GreenbergS L Schrier
Dec 1, 1965·Journal of Cellular Physiology·D H Pluznik, L Sachs