Myelosuppressive activity of two herbicides, atrazine and dinoterb, on human haematopoietic progenitor cells: An in vitro assay to evaluate the effects of intermediate or long-term exposure

Toxicology in Vitro : an International Journal Published in Association with BIBRA
B SawickiM C Léglise

Abstract

The effects of chronic exposure to phytosanitary products are difficult to determine because of their use in combination with other products and their variety of formulations containing additives or contaminants. In order to evaluate, at the cellular level, the risk of myelosuppressive effects caused by two widely used herbicides, atrazine and dinoterb, we performed in vitro assays on human granulo-monocytic progenitor-cells (CFU-GM) and also granulomonocytic expansion in liquid media. Both of these techniques were carried out in the presence of each molecule. Seven stable environmental metabolites of atrazine were studied using the above techniques in addition to supernatants of rat hepatocytes preincubated with atrazine and dinoterb for 24 hr. Parent atrazine and dinoterb showed similar moderate-direct toxicity on CFU-GM. In cells grown in liquid media for a period longer than 14 days, dinoterb toxicity appeared delayed but increased when compared with atrazine. 2-chloro-diamino-atrazine was found to be as toxic as atrazine on CFU-GM. Supernatants of rat hepatocyte preincubated for 24 hr with dinoterb exhibited a 150-fold increase in toxicity compared with the parent molecule, while toxicity remained unchanged for atrazine. T...Continue Reading

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Citations

Aug 21, 2003·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Chrisovalantis PapaefthimiouGeorge Theophilidis
Oct 14, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·G GiusiD Santucci
Mar 23, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Reginald F ClaytonArvind H Patel
Feb 21, 2021·The Science of the Total Environment·Lan LiuStéphane Bayen

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