Myenteric 5-HT-containing neurones activate the descending cholinergic excitatory pathway to the circular muscle of guinea-pig ileum.

British Journal of Pharmacology
J G JinS Nakayama

Abstract

1. Participation of myenteric 5-hydroxytryptamine (5-HT)-containing neurones in the ascending and descending pathways of the guinea-pig isolated ileum was investigated in a new preparation. Transmural electrical stimulation of the longitudinal muscle-myenteric plexus (LM-MP) portion of the preparation caused ascending and descending contractions of circular or longitudinal muscle in the attached, intact segments situated orally or anally to the point of stimulation. 2. All contractions of LM-MP stimulation were abolished by tetrodotoxin (0.2 microM). The ascending and descending contractions of circular muscles were also abolished by atropine and inhibited to about 50% by hexamethonium. They were not affected by desensitization to substance P (SP) or by the SP antagonist, (D-Pro2,D-Trp7,9)-substance P. The contractions of longitudinal muscles were inhibited by about 45% by hexamethonium and abolished by a combination of atropine with SP desensitization or the SP antagonist, (D-Pro2,D-Trp7,9)-substance P. 3. Desensitization to 5-HT, ICS 205-930 (1 microM) or cocaine (1 microM) reduced the descending contraction of circular muscle by 80-90%, without significantly affecting the ascending contraction. Methysergide (0.2 microM) fail...Continue Reading

References

Nov 16, 1979·European Journal of Pharmacology·J R FozardG Newgrosh
Mar 1, 1967·British Journal of Pharmacology and Chemotherapy·M D Gershon
Jan 1, 1981·Annual Review of Neuroscience·M D Gershon
Dec 1, 1984·Neuropharmacology·J R Fozard
Oct 1, 1963·British Journal of Pharmacology and Chemotherapy·G BROWNLEE, E S JOHNSON
May 11, 1899·The Journal of Physiology·W M Bayliss, E H Starling

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Citations

Jun 1, 1971·The American Journal of Digestive Diseases·A Bennett, B Fleshler
Jul 22, 1996·The Journal of Comparative Neurology·A L KirchgessnerM D Gershon

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