Myo- and cardiotoxic effects of the wild winter mushroom ( Flammulina velutipes) on mice

Experimental Biology and Medicine
Anne-Mari MustonenPetteri Nieminen

Abstract

Rhabdomyolysis (destruction of striated muscle) is a novel form of mushroom poisoning in Europe and Asia indicated by increased circulating creatine kinase levels. Particular wild fungi have also been reported to induce elevated creatine kinase activities in mice. Flammulina velutipes (enokitake or winter mushroom) is one of the most actively cultivated mushroom species globally. As it is marketed as a medicinal mushroom and functional food, it is important to examine whether it could induce potentially harmful health effects similar to some previously studied edible fungi. The present study examined the effects of F. velutipes consumption on the plasma clinical chemistry, hematology, and organ histology of laboratory mice. Wild F. velutipes were dried, pulverized, mixed with a regular laboratory rodent diet, and fed to the animals at 0, 3, 6, or 9 g/kg body mass/day for five days ( n = 6/group). F. velutipes consumption caused increased activities of plasma creatine kinase and the MB-fraction of creatine kinase at 6-9 g/kg/d, indicating potentially deleterious effects on both skeletal and cardiac muscle. The plasma total and high-density lipoprotein cholesterol concentrations (at 9 g/kg/d) and white blood cell and lymphocyte c...Continue Reading

References

Nov 1, 1975·Toxicon : Official Journal of the International Society on Toxinology·J Y LinG Y Shi
Nov 15, 1974·Nature·J Y LinT W Jeng
Sep 15, 2001·The New England Journal of Medicine·R BedryJ Beylot
Sep 25, 2003·Toxicon : Official Journal of the International Society on Toxinology·Christine Karlson-Stiber, Hans Persson
Nov 25, 2004·Journal of Experimental Zoology. Part A, Comparative Experimental Biology·Petteri NieminenAnne-Mari Mustonen
Dec 8, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Petteri NieminenMarkku Kirsi
Feb 17, 2005·Journal of Agricultural and Food Chemistry·Cheryl L DikemanGeorge C Fahey
Mar 19, 2005·Critical Care : the Official Journal of the Critical Care Forum·Ana L Huerta-AlardínPaul E Marik
Feb 1, 2006·Experimental Biology and Medicine·Petteri NieminenAnne-Mari Mustonen
May 24, 2006·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Anne-Mari MustonenPetteri Nieminen
Dec 29, 2006·Toxicological Reviews·Philippe Saviuc, Vincent Danel
Dec 7, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P NieminenA-M Mustonen
Feb 26, 2008·Experimental Biology and Medicine·Andrea T BorchersM Eric Gershwin
Nov 4, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Petteri NieminenAnne-Mari Mustonen
May 26, 2009·Nature Chemical Biology·Masanori MatsuuraMasaya Nakata
Aug 7, 2009·Experimental Biology and Medicine·Anne-Mari MustonenPetteri Nieminen
Nov 8, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Filipa S ReisIsabel C F R Ferreira
Oct 9, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kelvin J LaytonMaxim Zaitsev
Feb 28, 2014·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Kimberlie A Graeme
Sep 25, 2014·BioMed Research International·Ming-Yei YehLi-Yun Lin
Jan 27, 2015·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Ming WuXiaofan Fei
Apr 9, 2016·Journal of Basic and Clinical Pharmacy·Anroop B Nair, Shery Jacob
May 9, 2016·Environmental Science and Pollution Research International·M MleczekK Sobieralski

❮ Previous
Next ❯

Citations

Sep 1, 2018·Comprehensive Reviews in Food Science and Food Safety·Piotr Rzymski, Piotr Klimaszyk
Feb 19, 2021·Comprehensive Reviews in Food Science and Food Safety·Huili LiPeter E Mortimer

❮ Previous
Next ❯

Methods Mentioned

BETA
light microscopy

Software Mentioned

SPSS

Related Concepts

Related Feeds

Cardiotoxicity

Cardiotoxicity refers to the muscle damage or dysfunction of heart electrophysiology caused by drug intake or due to disease complications. It is a well-known side effect of several cytotoxic drugs, especially of the anthracyclines and can lead to long term morbidity. Here is the latest research.

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Petteri NieminenAnne-Mari Mustonen
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Petteri NieminenA-M Mustonen
Experimental Biology and Medicine
Petteri NieminenAnne-Mari Mustonen
Toxicon : Official Journal of the International Society on Toxinology
J Y LinG Y Shi
© 2022 Meta ULC. All rights reserved