PMID: 38395May 6, 1979

Myo-inositol-1-phosphate synthase from streptomyces griseus (studies on the biosynthesis of cyclitols, XXXVIII)

Molecular and Cellular Biochemistry
F PittnerO Hoffmann-Ostenhof

Abstract

It could be shown that Streptomyces griseus, the microorganism producing the antibiotic streptomycin and also mutant strains of this species that cannot synthesize streptomycin, possess myo-inositol-1-phosphate synthase (EC 5.5.1.4), the enzyme cyclizing D-glucose 6-phosphate. The enzyme isolated from that organism is extremely instable, its molecular weight is approximately 260,000, and it requires a divalent metal ion for its activity. This is the first instance that an enzyme of this specificity has been found in a prokaryotic organism.

Related Concepts

Microorganism
Phosphate Measurement
Streptomycin
Carbohydrate Epimerases
Isomerase
Glucose
Organism
Mutant
Myo-Inositol-1-Phosphate Synthase
Streptomyces griseus

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