Myo-inositol enhances teratogenicity of valproic acid in the mouse

Birth Defects Research. Part A, Clinical and Molecular Teratology
Valentina MassaRichard H Finnell

Abstract

Valproic acid (VPA) is an anticonvulsant drug that is widely used therapeutically for a variety of neurological conditions. VPA is also well known for its teratogenic potential in both humans and experimental animal models. The typical malformations observed following VPA exposure include neural tube defects (NTDs) and craniofacial and skeletal malformations. Nevertheless, the mechanisms underlying VPA's anticonvulsant efficacy or its teratogenicity remain to be elucidated. It was recently suggested that a relationship exists between VPA exposure and the cellular depletion of myo-inositol (INO). Furthermore, INO has been shown to rescue NTDs in the curly tail mouse. The aim of this study was to investigate the interactions of VPA and INO in the developing embryo. For this purpose, 2 strains of mice were used: SWV/Fnn (known to be sensitive to VPA) and LM/Bc (known to be resistant to VPA-induced NTDs). Pregnant females were randomly assigned to 4 experimental groups: control, VPA (600 mg/kg), INO (400 mg/kg), and VPA plus INO. VPA was injected IP at 8.5 days postcoitum (dpc). INO was administered PO twice a day from 6.5 to 10.5 dpc. At term the dams were killed, the uteri were removed, and all of the general toxicological parame...Continue Reading

References

Oct 1, 1990·Acta Paediatrica Japonica; Overseas Edition·T SonodaK Hayakawa
Jun 1, 1987·Teratology·E J LammerG P Oakley
Oct 1, 1985·Archives of Neurology·R B PaulsonG W Paulson
Nov 1, 1984·American Journal of Medical Genetics·J H DiLibertiC J Curry
Jan 1, 1996·Teratogenesis, Carcinogenesis, and Mutagenesis·E MenegolaE Giavini
Jan 1, 1997·Nature Medicine·N D Greene, A J Copp
May 1, 1998·Teratology·M KhandelwalM Borenstein
Feb 17, 2000·International Journal of Pharmaceutics·N Utoguchi, K L Audus
Nov 15, 2000·Lancet·R H Finnell, J Burn
Jan 25, 2002·Annual Review of Pharmacology and Toxicology·Richard H FinnellThomas H Rosenquist
Mar 23, 2002·Nutrition Reviews·Patricia BeemsterRégine Steegers-Theunissen
Oct 3, 2002·Journal of Neurochemistry·Stephen K FisherBernard W Agranoff
Jun 1, 2004·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Yunxia Wang LundbergRichard H Finnell
Dec 4, 2004·Biological Psychiatry·Galit ShaltielGalila Agam
Mar 4, 2005·Birth Defects Research. Part A, Clinical and Molecular Teratology·Gary M ShawDonna M Schaffer
Apr 1, 2005·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Nicholas D E Greene, Andrew J Copp
Apr 22, 2005·Journal of Perinatal Medicine·Johannes Dietl
May 21, 2005·Therapeutic Drug Monitoring·David N Bailey, John R Briggs

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Citations

Mar 22, 2008·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Makoto UsamiOsamu Doi
Oct 15, 2013·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Claudia Kappen
Jun 22, 2016·Birth Defects Research·Nicholas D E GreeneAndrew J Copp
Oct 19, 2019·Molecular Biology Reports·Ozlem OztopuzMetehan Uzun
May 8, 2021·Frontiers in Cell and Developmental Biology·Chiara ParodiValentina Massa

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