Myo-inositol in a new pharmaceutical form: a step forward to a broader clinical use

Expert Opinion on Drug Delivery
Gianfranco CarlomagnoFedele Manna

Abstract

Dose-dependent side effects related to myo-inositol (MI) oral administration represent a significant shortcoming for its clinical use. Aiming to search for a pharmaceutical form able to be better absorbed, the pharmacokinetic (PK) profile of the new manufactured MI soft gelatin capsule form was evaluated and compared with the commercially available MI powder. A single-dose relative trial, consisting of four phases, was performed on 20 healthy volunteers who received different doses of MI powder and MI soft gelatin capsules. PK profiles related to the two pharmaceutical forms were obtained by analysis of MI plasma concentration, and the respective MI bioavailability was compared. The administration of MI powder and MI soft gelatin capsules resulted in a different bioavailability. MI soft gelatin capsule form showed similar PK parameters compared with three times higher doses of MI in powder form. MI soft gelatin capsules displayed an improved bioavailability, allowing to substantially reduce the administered dose and to minimize the dose-dependent side effects. Considering the number of conditions in which MI supplementation is recommended, this evidence could support a broader use of MI in clinical practice.

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Citations

Jul 16, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·John E Nestler, Vittorio Unfer
Sep 7, 2012·Expert Opinion on Drug Delivery·Salvatore Benvenga
Jul 14, 2016·European Journal of Medicinal Chemistry·P M RendleK M Loomes
Jun 29, 2016·Expert Opinion on Drug Metabolism & Toxicology·Mariano BizzarriArturo Bevilacqua
Feb 7, 2014·Reproductive Sciences·Vittorio UnferJean-Patrice Baillargeon
Oct 21, 2017·International Journal of Molecular Sciences·Simona DinicolaMariano Bizzarri
Nov 16, 2016·International Journal of Endocrinology·Vittorio UnferFabio Facchinetti
Mar 20, 2019·Diabetes/metabolism Research and Reviews·Gloria FormosoAgostino Consoli
Sep 17, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Luc P BrionUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Nov 23, 2019·International Journal of Molecular Sciences·Anna WojciechowskaJoanna Wojtkiewicz
Dec 2, 2020·International Journal of Molecular Sciences·Karol WiśniewskiJoanna Wojtkiewicz
Jul 1, 2020·Clinical Therapeutics·John S MarkowitzBill J Gurley
Jun 26, 2021·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Mariano BizzarriAntonio Simone Laganà

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