Myocardial abnormalities underlying persistent ST-segment elevation after anterior myocardial infarction

Journal of Cardiovascular Medicine
Massimo NapodanoSabino Iliceto

Abstract

Persistence of ST-segment elevation after myocardial infarction has been ascribed to left ventricular aneurysm development. However, its pathophysiological basis is still undefined. This study sought to evaluate myocardial structural and functional abnormalities underlying persistent ST-segment elevation, using contrast-enhanced magnetic resonance imaging. Forty patients treated with primary angioplasty for a first anterior myocardial infarction underwent contrast-enhanced magnetic resonance imaging. Persistent ST-segment elevation was defined as ST-segment elevation of at least 2 mm in two or more leads on predischarge electrocardiogram. The presence and extent of myocardial necrosis and persistent microvascular damage, as well as wall motion abnormalities, were assessed by contrast-enhanced magnetic resonance imaging. At contrast-enhanced magnetic resonance imaging, patients with persistent ST-segment elevation had higher infarct size index (P=0.02) and showed transmural necrosis (P=0.03) and persistent microvascular damage (P=0.003) more often. Left ventricular aneurysm was seen more frequently in patients with ST-segment elevation (P=0.08). In a multivariate model, persistent microvascular damage was the only independent pr...Continue Reading

References

May 11, 1975·The American Journal of Cardiology·R M MillsM Lesch
Jan 1, 1976·Journal of Electrocardiology·K CohnF J Forlini
Apr 4, 1985·The New England Journal of Medicine·UNKNOWN TIMI Study Group
Aug 3, 1967·The New England Journal of Medicine·M V HermanR Gorlin
Mar 1, 2000·Circulation·M M Scheinman, L A Saxon
Nov 14, 2000·Circulation Research·R A LiE Marbán
Jan 15, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Thorsten ReffelmannRobert A Kloner
Oct 9, 2007·The American Journal of Cardiology·Cristina BassoSabino Iliceto

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Citations

Dec 20, 2012·The Western Journal of Emergency Medicine·Steven BaileyArun Nagdev
Mar 8, 2014·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Dhaval KolteDiwakar Jain
Aug 1, 2015·Emergency Medicine Clinics of North America·Jose V Nable, Benjamin J Lawner
Nov 13, 2021·Biotechnology and Applied Biochemistry·Farzaneh RostamzadehZeinab Ansari-Asl

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