Myocardial and hepatic free carnitine concentrations in pups of diabetic female rats

Annals of Nutrition & Metabolism
Mete AkisuAfig Huseyinov

Abstract

Adequate carnitine levels are required for normal fatty acid and energy metabolism in heart muscle. It is well known that streptozotocin-induced diabetic rats develop myocardial carnitine deficiency and that carnitine therapy may be beneficial to the diabetic heart. Infants of diabetic mothers (IDM) are known to be at risk for developing a hypertrophic type of cardiomyopathy. In the present investigation, we examined the free carnitine concentration from cardiac and hepatic tissue in pups of streptozotocin-induced diabetic female rats. We also assessed the effect of maternal L-carnitine supplementation on the free carnitine concentration in pups of diabetic rats. Three groups, each consisting of 4 Wistar albino female rats, were studied, Group 1 (untreated diabetic; n = 4) and group 2 (L-carnitine-treated diabetic; n = 4) rats were given streptozotocin (60 mg/kg) by intraperitoneal injection; group 3 were controls. During pregnancy, L-carnitine was given at a dose of 150 mg/kg by intraperitoneal injection once a day for 14 days. Cesarean section was carried out, and 113 newborn rats (group 1 n = 36; group 2 n = 38; group 3 n = 39) were obtained from all the pregnant rats. The free carnitine concentration in myocardial tissue wa...Continue Reading

Citations

Feb 22, 2007·European Journal of Clinical Nutrition·A PoorabbasM Vahed Jabbari
Jun 27, 2019·BMC Genomics·Danielly Beraldo Dos Santos SilvaLucia Galvão de Albuquerque

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