Myocardial and plasma renin-angiotensinogen dynamics during pressure-induced cardiac hypertrophy

The American Journal of Physiology
L J HellerS A Katz

Abstract

Plasma and left ventricular (LV) renin and angiotensinogen concentrations were assessed in a rat model of pressure-overload cardiac hypertrophy to determine if myocardial levels remained proportional to plasma levels over time. Three days after subdiaphragmatic aortic constriction (AC), LV hypertrophy was evident and renin concentrations in both plasma and LV, although not significantly elevated, were positively correlated with relative cardiac mass. After 42 days AC, LV hypertrophy remained, plasma and LV renin and angiotensinogen levels were not different from shams, and there was no correlation between renin and relative cardiac mass. Furthermore, LV renin and angiotensinogen concentrations remained at approximately 25 and 4%, respectively, of those in plasma throughout the experiment. Myocytes from 3-day AC and sham-treated rats contained little renin as did LV from 48-h anephric rats. Incubations using calculated concentrations of myocardial interstitial renin and angiotensinogen revealed significant angiotensin I generation. These data suggest that LV renin in this model varies directly with plasma renin, is confined to the interstitial space, and can generate significant intramyocardial angiotensin I.

References

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Citations

Nov 22, 2000·American Journal of Physiology. Heart and Circulatory Physiology·W S AkersL A Cassis
Jul 20, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Daniel F Catanzaro
Mar 11, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S A KatzL J Heller
Mar 15, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J J SarisA H Jan Danser
Nov 6, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J C B FerreiraP C Brum
Sep 16, 2004·American Journal of Physiology. Endocrinology and Metabolism·Wei XiangYan Chun Li
Sep 14, 2010·American Journal of Physiology. Heart and Circulatory Physiology·A H Jan Danser
Dec 4, 2008·American Journal of Physiology. Endocrinology and Metabolism·Jason D FowlerStephen A Katz

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