Myocardial apoptosis prevention by radical scavenging in patients undergoing cardiac surgery

The Journal of Thoracic and Cardiovascular Surgery
Uwe M FischerUwe Mehlhorn

Abstract

Reactive oxygen-derived species, including those generated during myocardial ischemia and reperfusion induced by cardioplegia, have been suggested to be involved in myocardial apoptosis induction. The purpose of our study was to investigate (1) whether cardioplegic arrest initiates apoptosis in the hearts of cardiac surgery patients and (2) whether reactive oxygen-derived species scavenging with N-acetylcysteine attenuates myocardial apoptosis initiation. In transmural left ventricular biopsy samples collected before and at the end of cardiopulmonary bypass, we densitometrically determined cardiac myocyte staining intensity for active caspases-3 and -7, the apoptosis signal pathway central effector enzymes. The left ventricular biopsy samples had been obtained from 36 coronary artery bypass graft patients randomized in a double-blind fashion to receive either N-acetylcysteine (100 mg/kg into cardiopulmonary bypass prime followed by infusion at 20 mg.kg(-1).h(-1); n = 18) or placebo (n = 18). The change in left ventricular cardiac myocyte staining (end of cardiopulmonary bypass minus before cardiopulmonary bypass) differed significantly between groups for both measures: caspase-3, -3.1 +/- 4.5 gray units (mean +/- SD; N-acetylcy...Continue Reading

References

Jul 1, 1996·Journal of the American College of Cardiology·J GurevitchV Yakirevich
Oct 17, 1996·The New England Journal of Medicine·J NarulaB A Khaw
Jan 21, 1997·Circulation·A SarasteL M Voipio-Pulkki
Apr 17, 1997·The New England Journal of Medicine·G OlivettiP Anversa
Jun 20, 1998·Circulation Research·A Haunstetter, S Izumo
May 10, 2001·Journal of Molecular and Cellular Cardiology·K SuzukiJ Schaper
Jan 5, 2002·Physiological Reviews·Wulf Dröge
May 9, 2002·The Annals of Thoracic Surgery·Joachim P SchmittHermann Aebert
Oct 19, 2002·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Petr DobsákM Horky
Jan 8, 2003·The Journal of Cell Biology·Jean-Ehrland RicciDouglas R Green
Jan 23, 2003·The Journal of Thoracic and Cardiovascular Surgery·Uwe MehlhornWilhelm Bloch
Jun 28, 2003·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Uwe M FischerUwe Mehlhorn
Jun 28, 2003·The Journal of Thoracic and Cardiovascular Surgery·James M HammelJeffrey L Segar

❮ Previous
Next ❯

Citations

Nov 8, 2011·Pediatric Cardiology·E Bernadette CabigasMichael E Davis
Jan 28, 2006·Heart and Vessels·Gokcen OrhanSerap Aykut Aka
Jan 24, 2007·Journal of Cardiothoracic Surgery·Evaristo CastedoJuan Ugarte
May 28, 2010·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·W T RuifrokW H van Gilst
Jul 20, 2010·Journal of Cardiothoracic and Vascular Anesthesia·Guyan WangDavy Cheng
Jul 25, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kwok M Ho, David J R Morgan
Feb 27, 2007·The Journal of Thoracic and Cardiovascular Surgery·Jiaquan ZhuHua Jing
Jan 5, 2006·British Journal of Clinical Pharmacology·Mirja-Liisa Aitio
Jan 15, 2011·Journal of Clinical Pharmacology·Erminio Sisillo, Giancarlo Marenzi
Jan 1, 2006·Multimedia Manual of Cardiothoracic Surgery : MMCTS·Hans J Geissler, Uwe Mehlhorn
Jul 19, 2008·Seminars in Cardiothoracic and Vascular Anesthesia·Francis Theodore Lytle, Daniel R Brown
Dec 2, 2005·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Fernando Lopez-NeblinaLuis H Toledo-Pereyra
Apr 24, 2020·Journal of Cardiovascular Pharmacology and Therapeutics·Erfan TasdighiMahnoosh Foroughi
Nov 7, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Uwe M FischerSteven J Allen
Feb 17, 2018·Asian Cardiovascular & Thoracic Annals·Pribadi Wiranda BusroAhmad Aulia Jusuf
Dec 22, 2007·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Oliver KlassUwe Mehlhorn

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis