Myocardial autophagic energy stress responses--macroautophagy, mitophagy, and glycophagy

American Journal of Physiology. Heart and Circulatory Physiology
Lea M D DelbridgeRoberta A Gottlieb

Abstract

An understanding of the role of autophagic processes in the management of cardiac metabolic stress responses is advancing rapidly and progressing beyond a conceptualization of the autophagosome as a simple cell recycling depot. The importance of autophagy dysregulation in diabetic cardiomyopathy and in ischemic heart disease - both conditions comprising the majority of cardiac disease burden - has now become apparent. New findings have revealed that specific autophagic processes may operate in the cardiomyocyte, specialized for selective recognition and management of mitochondria and glycogen particles in addition to protein macromolecular structures. Thus mitophagy, glycophagy, and macroautophagy regulatory pathways have become the focus of intensive experimental effort, and delineating the signaling pathways involved in these processes offers potential for targeted therapeutic intervention. Chronically elevated macroautophagic activity in the diabetic myocardium is generally observed in association with structural and functional cardiomyopathy; yet there are also numerous reports of detrimental effect of autophagy suppression in diabetes. Autophagy induction has been identified as a key component of protective mechanisms that...Continue Reading

References

Jul 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J S IngwallK Wildenthal
Jul 1, 1986·Cell Biology International Reports·E J de WaalJ James
Nov 1, 1995·The American Journal of Physiology·B A FineganA S Clanachan
Jan 1, 1996·Circulation Research·R SandhuG J Wilson
Jul 1, 1997·Cardiovascular Research·S Schaefer, R Ramasamy
Nov 14, 1998·The American Journal of Physiology·H FraserA S Clanachan
Oct 26, 1999·Cardiovascular Research·L F WangS Schaefer
Mar 7, 2001·European Journal of Pharmacology·R de JongeS Bradamante
Jul 12, 2002·Microscopy Research and Technique·S A KalamidasA C Hann
Jan 1, 2003·Current Neurology and Neuroscience Reports·Ichizo Nishino
Oct 3, 2003·The Journal of Biological Chemistry·Piyajit WatcharasitRichard S Jope
Dec 31, 2003·Journal of Applied Physiology·Claude LajoieLouise Béliveau
Jul 15, 2004·American Journal of Physiology. Endocrinology and Metabolism·Jing He, David E Kelley
Aug 3, 2004·Microscopy Research and Technique·Othon B KotoulasDimitrios J Kondomerkos
Nov 5, 2004·Nature·Akiko KumaNoboru Mizushima
Dec 24, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Peipei WangJohn C Chatham
Jul 4, 2007·The Journal of Clinical Investigation·Hongxin ZhuJoseph A Hill
Oct 13, 2007·Journal of Molecular and Cellular Cardiology·Masahiro NishiharaKazuaki Shimamoto
Nov 15, 2008·Cell Death and Differentiation·K NishidaK Otsu
Jan 31, 2009·Circulation Research·Asa B Gustafsson, Roberta A Gottlieb
Feb 27, 2009·Basic Research in Cardiology·Smadar YitzhakiRoberta A Gottlieb
Apr 4, 2009·The American Journal of Pathology·Hiromitsu KanamoriShinya Minatoguchi
Aug 22, 2009·The Journal of Biological Chemistry·Arunima SenguptaKatherine E Yutzey
Dec 17, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Chengqun HuangRoberta A Gottlieb
Jan 20, 2010·FEBS Letters·Chang Hwa JungDo-Hyung Kim
Apr 7, 2010·Autophagy·Raquel S CarreiraRoberta A Gottlieb
Apr 15, 2010·Proteomics·David StapletonGlendon Parker
May 11, 2010·Human Molecular Genetics·Carmen AguadoDavid C Rubinsztein
Jun 19, 2010·Journal of Cardiovascular Translational Research·Chengqun HuangRoberta A Gottlieb
Sep 3, 2010·The Journal of Biological Chemistry·Sixin JiangPeter J Roach
Nov 16, 2010·Annals of Neurology·Julie TurnbullBerge A Minassian
Nov 17, 2010·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Chiara AlfaranoLaura Raimondi
Dec 21, 2010·Pediatric Cardiology·Sebastiano SciarrettaJunichi Sadoshima
Jan 15, 2011·Cardiovascular Research·François VigneronBéatrice Jaspard-Vinassa
Jan 21, 2011·Pediatric Cardiology·Joseph A Hill
Feb 3, 2011·Cell Metabolism·Mantong Zhao, Daniel J Klionsky

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Citations

Sep 20, 2015·International Journal of Cardiology·Pujika Emani MunasingheRajesh Katare
Aug 7, 2016·Frontiers in Neuroanatomy·Paola LenziFrancesco Fornai
Nov 2, 2016·Journal of Cellular Physiology·Hye Kyoung SungGary Sweeney
Jul 28, 2017·Nature Reviews. Cardiology·Robert A KlonerJianru Shi
Feb 25, 2018·Nature Cell Biology·Damián GaticaDaniel J Klionsky
Nov 15, 2017·Scientific Reports·Ana Elisa Teófilo Saturi de CarvalhoJosé Eduardo Krieger
Jul 17, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Wendy T K IpLea M D Delbridge
Dec 6, 2017·Journal of the American Heart Association·Lee B BockusKenneth M Humphries
May 5, 2018·Stroke; a Journal of Cerebral Circulation·Kyeong-A KimOk-Nam Bae
Oct 13, 2017·Circulation. Heart Failure·Sonia R SinghLucie Carrier
Nov 13, 2018·Antioxidants & Redox Signaling·Lorna J DanielsLea M D Delbridge
Nov 13, 2018·Annual Review of Animal Biosciences·S PanseratS Skiba-Cassy
Mar 27, 2018·Oxidative Medicine and Cellular Longevity·Rajeshwary Ghosh, J Scott Pattison
Nov 30, 2019·Oxidative Medicine and Cellular Longevity·Vicente Roca-AgujetasAnna Colell
Jul 23, 2015·BMB Reports·Youn Wook Chung, Seok-Min Kang
Oct 31, 2017·Current Pathobiology Reports·Roberta A Gottlieb, Amandine Thomas
Jul 21, 2020·Autophagy·Sophie TesseraudIban Seiliez
Nov 7, 2019·Cell Reports·Alicia Mayeuf-LouchartHélène Duez
Mar 16, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chao LinHuimin Bian
May 1, 2021·International Journal of Molecular Sciences·Laura DobladoMaria Monsalve
Nov 7, 2020·Chemical Society Reviews·Siyang Ding, Yuning Hong
Jun 12, 2021·Circulation Research·Min XieJoseph A Hill
Jul 3, 2021·Antioxidants·Andrea Gila-DiazDavid Ramiro-Cortijo
Jul 20, 2021·Frontiers in Medicine·Teresa SalvatoreFerdinando Carlo Sasso

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