PMID: 9538939Apr 16, 1998Paper

Myocardial blood flow in awake dogs with chronic tricuspid regurgitation

Basic Research in Cardiology
R P BaumanJ C Greenfield

Abstract

The primary purpose of this study was to define regional blood flow in dogs with chronic tricuspid regurgitation (TR) in order to determine if the marked hypertrophy of the right atria resulted in compromised myocardial perfusion. Myocardial blood flow (ml/min/gm) was measured with radiolabeled microspheres in eight dogs with TR during rest, moderate exercise (5 dogs), and infusion of adenosine (1 mg/kg/min), an index of minimal vascular resistance. Similar measurements were obtained in eight normal dogs. In TR, the ratio of right atrium (RA) and right ventricle (RV) to body weight was greater than in normal dogs, 77% and 30%, respectively. During rest, flow in the RA appendage was less than in nonappendage region in the normal dogs; no differences were noted in TR dogs, indicating an augmented hemodynamic role of the appendage in TR. Both RA and RV blood flow was greater in TR during rest but no other differences in flow were found between the two groups. Minimum vascular resistance in RV but not RA was slightly increased in TR versus normal. During marked myocyte hypertrophy, the vasculature of RA develops sufficiently to provide the same flow capacity as in the normal heart.

Citations

Aug 10, 2004·Current Opinion in Nephrology and Hypertension·José A García-DonaireLuis M Ruilope
Nov 13, 2015·Interactive Cardiovascular and Thoracic Surgery·Xu-jing XieHuan-lei Huang
Feb 14, 2007·Journal of Vascular and Interventional Radiology : JVIR·Hanno HoppeJosef Rösch
Aug 5, 2000·The Journal of Thoracic and Cardiovascular Surgery·A S ShahD D Glower
Jul 4, 2006·Physiological Reviews·Martin PaulReinhold Kreutz
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Ares D PasipoularidesDonald D Glower
Dec 21, 2000·American Journal of Physiology. Heart and Circulatory Physiology·Y IshibashiG Cooper

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