Myocardial Collagen Cross-Linking Is Associated With Heart Failure Hospitalization in Patients With Hypertensive Heart Failure

Journal of the American College of Cardiology
Begoña LópezJavier Díez

Abstract

Excessive myocardial collagen cross-linking (CCL) determines myocardial collagen's resistance to degradation by matrix metalloproteinase (MMP)-1 and interstitial accumulation of collagen fibers with impairment of cardiac function. This study sought to investigate whether CCL and a newly identified biomarker of this alteration are associated with hospitalization for heart failure (HHF) or cardiovascular death in patients with HF and arterial hypertension in whom other comorbidities were excluded. Endomyocardial biopsies and blood samples from 38 patients (invasive study), and blood samples from 203 patients (noninvasive study) were analyzed. Mean follow-ups were 7.74 ± 0.58 years and 4.72 ± 0.11 years, respectively. Myocardial CCL was calculated as the ratio between insoluble and soluble collagen. The ratio between the C-terminal telopeptide of collagen type I (CITP) and matrix metalloproteinase-1 (CITP:MMP-1) was determined in blood samples. Invasive study: CCL was increased (p < 0.001) in patients compared with controls. Patients were categorized according to normal or high CCL values. Patients with high CCL exhibited higher risk for subsequent HHF (log-rank test p = 0.022), but not for cardiovascular death. CITP:MMP-1 was inv...Continue Reading

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Citations

Jan 23, 2016·Journal of the American College of Cardiology·James C MoonErik B Schelbert
Oct 30, 2016·Journal of Cardiac Failure·Walter J Paulus
Oct 3, 2017·ESC Heart Failure·Akiomi YoshihisaYasuchika Takeishi
Aug 9, 2017·Journal of the American Heart Association·Zhen-Yu ZhangJan A Staessen
Jan 7, 2017·Circulation Research·Mark R Thomas, Gregory Y H Lip
Jul 30, 2016·Circulation. Heart Failure·Karl T Weber, Javier Díez
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Nov 23, 2019·Aging·Susana RavassaJavier Díez
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Oct 26, 2018·Hypertension·Arantxa GonzálezJavier Díez
Feb 25, 2017·Current Hypertension Reports·Marty C TamScott L Hummel
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May 2, 2020·Journal of the American College of Cardiology·Javier DíezJason C Kovacic
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Feb 12, 2021·Nature Reviews. Cardiology·Begoña LópezJavier Díez
Feb 4, 2021·JACC. Basic to Translational Science·Emily S LauJennifer E Ho

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