Myocardial contractile efficiency and oxygen cost of contractility are preserved during transition from compensated hypertrophy to failure in rats with salt-sensitive hypertension

Hypertension
I MoriiS Sasayama

Abstract

In Dahl-Iwai rats, salt-sensitive hypertension causes concentric left ventricular hypertrophy (LVH) at the age of 11 weeks, which is followed by LV dilatation with global hypokinesis and pulmonary congestion, ie, LV failure (LVF), at 16 to 18 weeks of age. To address the question of whether the cardiac remodeling from LVH to LVF is associated with modulations of mechanoenergetic properties, we serially measured the LV pressure-volume area (PVA) and myocardial oxygen consumption (MVO2) in isolated, isovolumically contracting hearts from this animal model. The end-systolic pressure-volume relationships obtained by stepwise changes of the LV volume were fit into a binominal regression model, which provided a value of LV contractility (E(es)) and a volume intercept (V0). A slope (the reciprocal of the LV contractile efficiency) and a PVA-independent MVO2 were determined by a regression analysis of the MVO2-PVA relation. The procedure was repeated at different Ca2+ concentrations in perfusate to estimate the oxygen cost of contractility (dMVO2/dE(es)). The MVO2 was further evaluated during K+-induced cardiac arrest to delineate the basal metabolism, which was independent of the E-C coupling. During the transition from LVH to LVF, th...Continue Reading

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Citations

Feb 19, 2002·Journal of the American College of Cardiology·Gavin R NortonTheo E Meyer
Jul 31, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yuichi KoideSatoshi Umemura
Jan 26, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hiroshi HasegawaIssei Komuro
Mar 25, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Minori NakamotoShuichi Takishita
Jul 11, 2001·Biochemical and Biophysical Research Communications·A Yasaka, W Hayashida
Mar 29, 2001·Journal of Molecular and Cellular Cardiology·W HayashidaS Sasayama
Mar 31, 2009·Journal of Hypertension·Giovanni de SimoneOreste de Divitiis
May 19, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·F Muders, D Elsner
Jul 13, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Kenneth TranDenis S Loiselle
Mar 27, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Callum M JohnstonAndrew J Taberner
Sep 20, 2000·American Journal of Physiology. Heart and Circulatory Physiology·P SegersN Westerhof

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