Myocardial creep-induced misalignment artifacts in PET/MR myocardial perfusion imaging.

European Journal of Nuclear Medicine and Molecular Imaging
Elia von FeltenRonny R Buechel

Abstract

Misalignment between positron emission tomography (PET) datasets and attenuation correction (AC) maps is a potential source of artifacts in myocardial perfusion imaging (MPI). We assessed the impact of adenosine on the alignment of AC maps derived from magnetic resonance (MR) and PET datasets during MPI on a hybrid PET/MR scanner. Twenty-eight volunteers underwent adenosine stress and rest 13N-ammonia MPI on a PET/MR. We acquired Dixon sequences for the creation of MRAC maps. After reconstruction of the original non-shifted PET images, we examined MRAC and PET datasets for cardiac spatial misalignment and, if necessary, reconstructed a second set of shifted PET images after manually adjusting co-registration. Summed rest, stress, and difference scores (SRS, SSS, and SDS) were compared between shifted and non-shifted PET images. Additionally, we measured the amount of cranial movement of the heart (i.e., myocardial creep) after termination of adenosine infusion. Realignment was necessary for 25 (89.3%) stress and 12 (42.9%) rest PET datasets. Median SRS, SSS, and SDS of the non-shifted images were 6 (IQR = 4-7), 12 (IQR = 7-18), and 8 (IQR = 2-11), respectively, and of the shifted images 2 (IQR = 1-6), 4 (IQR = 7-18), and 1 (IQR...Continue Reading

References

Oct 1, 1984·Radiology·W T Dixon
Nov 4, 1998·Medical Physics·P E KinahanD Sashin
Jun 19, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·K Lance GouldStefano Sdringola
Feb 6, 2008·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·T F Chan, L A Vese
Mar 18, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Axel Martinez-MöllerStephan G Nekolla
Jun 21, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Jan VontobelPhilipp A Kaufmann
Feb 12, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Christoph KolbitschTobias Schaeffter
Sep 3, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·John R Votaw, René R Sevag Packard
Nov 24, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Martin Lyngby LassenThomas Beyer
Mar 25, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Benjamin C LeeVenkatesh L Murthy
May 29, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Sharmila DorbalaR Glenn Wells
Nov 15, 2018·Physics in Medicine and Biology·Philip M RobsonZahi A Fayad
Feb 23, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·S S KoendersJ A van Dalen

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