Myocardial damage in dogs affected by heartworm disease (Dirofilaria immitis): immunohistochemical study of cardiac myoglobin and troponin I in naturally infected dogs

Veterinary Parasitology
E CarretónJ A Montoya-Alonso

Abstract

It has recently been reported that dogs affected by canine heartworm disease (Dirofilaria immitis) can show an increase in plasma levels of myoglobin and cardiac troponin I, two markers of muscle/myocardial injury. In order to determine if this increase is due to myocardial damage, the right ventricle of 24 naturally infected dogs was examined by routine histology and immunohistochemistry with anti-myoglobin and anti-cardiac troponin I antibodies. Microscopic lesions included necrosis and myocyte vacuolization, and were associated with loss of staining for one or both proteins. Results confirm that increased levels of myoglobin and cardiac troponin I are indicative of myocardial damage in dogs affected by heartworm disease.

References

Apr 10, 2003·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Michael C FishbeinFred S Apple
Oct 7, 2004·The American Journal of Cardiology·Susan M SallachJames McCord
Oct 22, 2008·Veterinary Parasitology·J W McCallB Carson
Mar 17, 2009·Journal of the American Veterinary Medical Association·Leslie C SharkeyRebecca L Hegstad-Davies
Apr 28, 2009·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Adrian Boswood
Mar 31, 2010·Coronary Artery Disease·Vikas SinghWilliam W O'Neill
Feb 12, 2011·Veterinary Parasitology·E CarretónJ A Montoya-Alonso

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Citations

Mar 1, 2014·Veterinary Parasitology·Susan E LittleMason V Reichard
Dec 19, 2015·Journal of Veterinary Internal Medicine·R Langhorn, J L Willesen
Sep 17, 2014·Veterinary Parasitology·E CarretónJ A Montoya-Alonso
Feb 13, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·T BoucheryC Martin
Nov 17, 2017·Parasites & Vectors·Elena CarretónJosé Alberto Montoya-Alonso
Jul 18, 2020·Frontiers in Veterinary Science·Alessandra GavazzaMatteo Cerquetella

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