PMID: 8952343Jan 1, 1996Paper

Myocardial damage in thyrotoxicosis--ultrastructural studies

Polish Journal of Pathology : Official Journal of the Polish Society of Pathologists
A WajdowiczM Zaczek

Abstract

Lack of uniform views concerning subcellular image and possible meaning of free radicals in the myocardial damage prompted us to study rat hearts submitted for chronic thyrotoxicosis. The studies were performed on 30 Wistar white rats. The material was obtained from anterior wall of the left ventricle of the heart. To confirm the role of free radicals one group of rats was given ascorbic acid, a well-known substance with anti-oxidation properties (free radical scavenger). In the control group we observed a typical structure of the myocardium. In the group with thyrotoxicosis a great degree of subcellular structural damage was noticed. These alterations correspond to nonspecific myocardial damage that can be meet in hypoxia, reperfusion or in toxic myocardial damage. However, in case of vitamin application generally known to have anti-oxidation properties, damages were significantly less intensive and occurred more rarely. It seems to indicate a significant role of free radicals in the generation of these alterations.

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

FEBS Letters
Marjolaine RocheEmmanuel Bourdon
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Ping LuShu-qing Shun
© 2021 Meta ULC. All rights reserved