Myocardial depressant effects of diethylcarbamazine citrate in vitro

European Journal of Pharmacology
J A Ojewole, I V Onejeme

Abstract

The effects of diethylcarbamazine citrate (DECC) have been examined in isolated, electrically driven left atria of guinea-pigs. This anthelmintic drug (DECC, 10(-9) -10(-4) M) produced a sustained, concentration-dependent depression of atrial contractile tension that was reversible by replacing the incubation fluid with DECC-free physiological solution. The negative inotropic response induced by DECC was antagonized in a competitive manner by increasing the calcium ion (Ca2+) concentration of the bathing fluid. On the contrary, the myocardial depressant effects of DECC were antagonized in a non-competitive manner by noradrenaline (NA). The present findings suggest a direct negative inotropic effect of DECC and indicate that this anthelmintic drug interferes with the empirical function of Ca2+ in the events leading to mechanical activity of the isolated atrial myocardium.

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Citations

Jan 1, 1986·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·S R Li, D X Wang
Jul 1, 1989·American Journal of Respiratory Cell and Molecular Biology·H W FarberF L Glauser
Feb 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·H W FarberF L Glauser

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