PMID: 9647067Jul 1, 1998Paper

Myocardial distribution of antegrade cold crystalloid and tepid blood cardioplegia

The Annals of Thoracic Surgery
I G DuarteR A Guyton

Abstract

Tepid blood (TB) cardioplegia combines the improved rheologic characteristics and the augmented oxygen and substrate delivery of blood cardioplegia with the advantages of moderate hypothermia. In addition, the intramyocardial distribution of continuous TB cardioplegia may also be better than intermittent cold crystalloid (CC) cardioplegia. We sought to compare the distribution of TB and CC cardioplegia at varying infusion pressures. In situ, isolated canine hearts were randomized to antegrade, continuous TB (28 degrees C, n = 8) or intermittent CC (n = 8) cardioplegia infused at 50, 75, and 100 mm Hg. The regional distribution of cardioplegia at each pressure was measured by 15-microm colored microspheres. Cardioplegia distribution was measured from three areas each of the right ventricle (inflow, outflow, and apex) and the left ventricle (anterior, lateral, and posterior). Left ventricular samples were subdivided into subepicardial, midmyocardial, and subendocardial. Delivery of cardioplegia to all areas of the right and left ventricles showed a linear pressure-flow relationship over the range of pressures tested. Right ventricular distribution was two-thirds of that to the left ventricle, and left ventricular subepicardial di...Continue Reading

References

Jul 1, 1977·Progress in Cardiovascular Diseases·M A HeymannA M Rudolph
Oct 1, 1991·The Annals of Thoracic Surgery·J Vinten-JohansenA R Cordell
Apr 1, 1988·Circulation Research·S YonekuraH F Downey
Aug 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·H SatoJ Vinten-Johansen
Oct 1, 1995·The Annals of Thoracic Surgery·C O MurphyR A Guyton
Jul 1, 1995·Journal of Cardiac Surgery·J W Hammon, J Vinten-Johansen
Jan 1, 1993·Annual Review of Pharmacology and Toxicology·A M Lefer, D J Lefer
Jan 1, 1996·Cardiovascular Research·H SatoJ Vinten-Johansen

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Citations

Sep 2, 2000·The Annals of Thoracic Surgery·D F TorchianaW M Daggett
Sep 13, 2000·Scandinavian Cardiovascular Journal : SCJ·K Lindmark, K G Engström
Sep 28, 2001·British Journal of Anaesthesia·J S HanC H Park

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