Jun 1, 1996

Myocardial dysfunction after successful resuscitation from cardiac arrest

Critical Care Medicine
Raúl J GazmuriD McKee

Abstract

To investigate the functional and metabolic changes in the myocardium after successful resuscitation from cardiac arrest. Prospective, randomized, sham-controlled study. Animal laboratory at a university center. Domestic pigs. Electric induction of ventricular fibrillation by alternating current delivered to the right ventricular endocardium through a pacing electrode. Electric defibrillation was attempted after an interval of 12 mins of ventricular fibrillation, which included 4 mins of untreated ventricular fibrillation and 8 mins of precordial compression in 13 animals, seven of which were successfully resuscitated. Seven additional animals were randomized to serve as "sham" controls, in which cardiac arrest was not induced. Left ventricular pressure-volume relationships utilizing the conductance method were obtained in conjunction with conventional hemodynamic and metabolic measurements at baseline and during a 6-hr interval after successful cardiac resuscitation. Progressive and striking increases in left ventricular volumes were observed after successful cardiac resuscitation. The end-diastolic volume increased from a prearrest level of 89 +/- 21 mL to a maximum of 154 +/- 53 mL (p<.05) at 360 mins after successful resusc...Continue Reading

Mentioned in this Paper

Myocardial Contraction
Ventricular Fibrillation
Ventricular Dysfunction, Left
Basic Cardiac Life Support
Cardiomyopathies
Electrical Injuries
Hemodynamics
Family suidae
Arrhythmogenic Right Ventricular Dysplasia, Familial,1 (Disorder)
Metazoa

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