PMID: 9416726Jan 7, 1998Paper

Myocardial effects of halothane and isoflurane in hamsters with hypertrophic cardiomyopathy

Anesthesiology
B VivienB Riou

Abstract

The effects of halothane and isoflurane on myocardial contraction and relaxation in diseased myocardium are not completely understood. The effects of equianesthetic concentrations of halothane and isoflurane on inotropy and lusitropy in left ventricular papillary muscles of healthy hamsters and those with genetically induced cardiomyopathy (strain BIO 14.6) were investigated in vitro (29 degrees C; pH 7.40; Ca2+ 2.5 mM; stimulation frequency, 3/min) in isotonic and isometric conditions. Halothane induced a negative inotropic effect that was greater in cardiomyopathic than in healthy hamsters (1.5 vol%, active isometric force (AF): 19 +/- 8% vs. 28 +/- 11% of control values; P < 0.05). Isoflurane induced a negative inotropic effect that was greater in cardiomyopathic than in healthy hamsters (2.0 vol%, AF: 64 +/- 13% vs. 75 +/- 11% of control values; P < 0.01). However, the negative inotropic effects of halothane and isoflurane were not different for cardiomyopathic or healthy hamsters when their concentrations were corrected for minimum alveolar concentration (MAC) values in each strain. Halothane induced a negative lusitropic effect under low load, which was more important in cardiomyopathic hamsters, suggesting a greater impa...Continue Reading

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Citations

Jun 11, 2005·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Maninder KalraRaouf S Amin
Jan 19, 2000·Anesthesiology·B Riou
Apr 29, 2004·Anesthesiology·Jean-Stéphane DavidBruno Riou
Dec 3, 2002·Anesthesiology·Sandrine RozenbergBruno Riou
Apr 3, 2007·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Paul S Pagel
Sep 1, 2016·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·D M TanakaM V Simões
Jan 17, 2014·The Journal of Pharmacology and Experimental Therapeutics·Xiaoxu ShenWei Dong Gao
Sep 14, 2019·The Journal of Pharmacology and Experimental Therapeutics·Tao MengWei Dong Gao
Jun 29, 2002·Anesthesia and Analgesia·Benoît VivienBruno Riou

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