Myocardial Energetics in Obesity: Enhanced ATP Delivery Through Creatine Kinase With Blunted Stress Response.

Circulation
Jennifer J RaynerOliver J Rider

Abstract

Obesity is strongly associated with exercise intolerance and the development of heart failure. Whereas myocardial energetics and diastolic function are impaired in obesity, systolic function is usually preserved. This suggests that the rate of ATP delivery is maintained, but this has never been explored in human obesity. We hypothesized that ATP transfer rate through creatine kinase (CK) (kfCKrest) would be increased, compensating for depleted energy stores (phosphocreatine/ATP), but potentially limiting greater ATP delivery during increased workload. We hypothesized that these changes would normalize with weight loss. We recruited 80 volunteers (35 controls [body mass index 24±3 kg/m2], 45 obese [body mass index 35±5 kg/m2]) without coexisting cardiovascular disease. Participants underwent body composition analysis, magnetic resonance imaging of abdominal, liver, and myocardial fat content, left ventricular function, and 31P magnetic resonance spectroscopy to assess phosphocreatine/ATP and CK kinetics, at rest and during dobutamine stress. Obese volunteers were assigned to a dietary weight loss intervention, before reexamination. At rest, although myocardial phosphocreatine/ATP was 14% lower in obesity (1.9±0.3 versus 2.2±0.2,...Continue Reading

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Citations

Apr 7, 2020·Circulation·Barry A Borlaug, Craig R Malloy
Jul 4, 2020·European Journal of Heart Failure·Vishal N RaoG Michael Felker
Feb 5, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jack J MillerDamian J Tyler
Feb 26, 2021·Metabolism: Clinical and Experimental·Christopher AugerMarc G Jeschke
May 15, 2021·Heart·Sarah L AytonAlastair J Moss
May 6, 2021·Physiological Reviews·Jun RenYingmei Zhang
Aug 29, 2021·European Heart Journal Cardiovascular Imaging·Andrew J M LewisOliver J Rider
Sep 21, 2021·European Heart Journal·Jennifer J RaynerOliver J Rider
Aug 11, 2020·JACC. Cardiovascular Imaging·Barry A Borlaug, Arnold C T Ng

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

AMARES
MATLAB
SPSS
TriST

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