Myocardial "equilibration processes" and myocardial energy turnover during initiation of artificial cardiac arrest with cardioplegic solution - reasons for a sufficiently long cardioplegic perfusion

The Thoracic and Cardiovascular Surgeon
C J PreusseH J Bretschneider

Abstract

In canine hearts the myocardial equilibration processes (temperature, pO2, pCO2, Na+, K+) and the myocardial energy turnover were analyzed at the beginning of a cardioplegically induced cardiac arrest during a coronary perfusion of 10 minutes. The investigated hearts (n = 10) were perfused with the Bretschneider histidine-buffered cardioplegic solution according to the recommendations worked out for clinical use. The results show that during the cardioplegic coronary perfusion of 10 minutes the cooling and temperature equilibration of the myocardium occur considerably faster than the establishment of a new energy steady-state at a very low level. The minimalization of the coronary resistance and of the myocardial O2 consumption are only reached after an extended perfusion period of 7 to 9 minutes. In consequence of the results, the following recommendations can be given for the clinical use of the Bretschneider cardioplegic solution: a) the solution should be used at a temperature of between 5 degrees and 10 degrees C, b) the cardioplegic coronary flow should be between 60 and 80 ml/min . 100 gww, c) the human heart should be perfused for 8 to 10 minutes and, d) the perfusion pressure should be maintained at 40 to 50 mmHg after...Continue Reading

Citations

May 9, 2003·The Annals of Thoracic Surgery·Torsten DoenstFriedhelm Beyersdorf
Dec 1, 1989·Pflügers Archiv : European journal of physiology·E KrohnH J Bretschneider
Jan 1, 1991·Scandinavian Journal of Thoracic and Cardiovascular Surgery·O LundM A Knudsen
Jan 1, 1991·Scandinavian Journal of Thoracic and Cardiovascular Surgery·L FrostH E Hansen
Sep 24, 2013·Scandinavian Cardiovascular Journal : SCJ·Mario GaudinoMassimo Massetti
Dec 23, 2015·Advanced Biomedical Research·Saeed Fazelifar, Hamid Bigdelian
Sep 26, 2000·The Journal of Thoracic and Cardiovascular Surgery·C StammP J Del Nido
Oct 1, 1990·European Journal of Clinical Investigation·U LeonhardtW Creutzfeldt
May 27, 2020·Cell and Tissue Banking·Ismini KoulouriFilip Filev
Sep 15, 1988·Klinische Wochenschrift·H J BretschneiderG Kehrer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.