PMID: 9534942Apr 16, 1998Paper

Myocardial fibrosis rather than hypertrophy induces diastolic dysfunction in renovascular hypertensive rats

Canadian Journal of Physiology and Pharmacology
L S MatsubaraA C Cicogna

Abstract

The aim of the present study was to evaluate the effect of interstitial fibrosis alone or associated with hypertrophy on diastolic myocardial function in renovascular hypertensive rats. Myocardial function was evaluated in isolated papillary muscle from renovascular hypertensive Wistar rats (RHT, n = 14), renovascular hypertensive rats treated with the angiotensin converting enzyme inhibitor (ACEI) ramipril, 20 mg.kg-1.day-1 (RHT RAM, n =14), and age-matched unoperated and untreated Wistar rats (CONT, n = 12). The ACEI treatment for 3 weeks allowed the regression of myocyte mass and the maintenance of interstitial fibrosis. Myocardial passive stiffness was analyzed by the resting tension-length relationship. The myocardial fibrosis was evaluated by measuring myocardial hydroxyproline (Hyp) concentration and by histological studies of the myocardium stained with hematoxylin and eosin or picrosirus red. Left ventricular weight was significantly higher in RHT (0.97 +/- 0.12 g) compared with CONT (0.66 +/- 0.06 g) and RHT RAM (0.69 +/- 0.14 g). The Hyp levels were 2.9 +/- 0.4, 3.4 +/- 0.3, and 3.8 +/- 0.4 micrograms/mg of dry tissue for the CONT, RHT, and RHT RAM, respectively. Perivascular and interstitial fibrosis were observed i...Continue Reading

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Citations

Mar 7, 2014·Canadian Journal of Physiology and Pharmacology·Karla Fabiana GoesslerMarcos Doederlein Polito
Jul 18, 2006·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Torkel FalkHenrik D Pedersen
Aug 3, 2002·Hypertension·M Mitchell LindsayFrancis G Dunn
Feb 18, 2005·Cardiovascular Drugs and Therapy·Makoto NagaiSeibu Mochizuki
Sep 21, 2007·Clinical and Experimental Pharmacology & Physiology·Maria C GuidoLuiz C Godoy
May 3, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Michel SlamaEdward D Frohlich
May 9, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Makoto KawaiMichihiro Yoshimura

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