Myocardial fibrosis seen through the lenses of T-cell biology

Journal of Molecular and Cellular Cardiology
Gustavo RamosStefan Frantz

Abstract

Lymphocytes came recently into focus as modulators of non-infectious myocardial diseases. Several lines of experimental evidence now indicate that CD4(+) T-cells can influence the healing and scarring processes that follow a myocardial infarction episode. Furthermore, such heart-directed T-cell activity has also been implicated in the pathogenesis cardiac remodeling that develops in response to chronic pressure-overload conditions. Mechanistically, different T-cell subsets can secrete several mediators and growth factors that influence the myocardial molecular milieu and directly interfere with the macrophages' and fibroblasts' activity. Therefore, the present review summarizes the current experimental evidence on the role of T-cells in myocardial scar formation after infarction and myocardial fibrosis as central mechanism of ventricular remodeling.

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Citations

Jul 15, 2016·Cell and Tissue Research·Ida G LundeGeir Christensen
Mar 4, 2017·Proceedings of the National Academy of Sciences of the United States of America·Gustavo Campos RamosUlrich Hofmann
Aug 14, 2019·The Journal of Clinical Investigation·Max RieckmannGustavo Campos Ramos
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Mar 23, 2018·Basic Research in Cardiology·Zhen-Guo MaQi-Zhu Tang
Jul 30, 2018·Molecular Aspects of Medicine·Nikolaos G Frangogiannis

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