PMID: 11312153Apr 20, 2001Paper

Myocardial gene expression of glucose transporter 1 and glucose transporter 4 in response to uteroplacental insufficiency in the rat

The Journal of Endocrinology
A E TsirkaR H Lane

Abstract

Uteroplacental insufficiency causes intrauterine growth retardation (IUGR) and subsequent low birth weight, which predisposes the affected newborn towards adult Syndrome X. Individuals with Syndrome X suffer increased morbidity from adult ischemic heart disease. Myocardial ischemia initiates a defensive increase in cardiac glucose metabolism, and individuals with Syndrome X demonstrate reduced insulin sensitivity and reduced glucose uptake. Glucose transporters GLUT1 and GLUT4 facilitate glucose uptake across cardiac plasma membranes, and hexokinase II (HKII) is the predominant hexokinase isoform in adult cardiac tissue. We therefore hypothesized that GLUT1, GLUT4 and HKII gene expression would be reduced in heart muscle of growth-retarded rats, and that reduced gene expression would result in reduced myocardial glucose uptake. To prove this hypothesis, we measured cardiac GLUT1 and GLUT4 mRNA and protein in control IUGR rat hearts at day 21 and at day 120 of life. HKII mRNA quantification and 2-deoxyglucose-uptake studies were performed in day-120 control and IUGR cardiac muscle. Both GLUT1 and GLUT4 mRNA and protein were significantly reduced at day 21 and at day 120 of life in IUGR hearts. HKII mRNA was also reduced at day 1...Continue Reading

Citations

Apr 8, 2006·Journal of Inherited Metabolic Disease·Nadia A OeyFrits A Wijburg
Dec 1, 2010·Journal of Developmental Origins of Health and Disease·G D WadleyG K McConell
Apr 15, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Qi FuRobert A McKnight
Feb 18, 2012·American Journal of Physiology. Endocrinology and Metabolism·Afshan AbbasiSherin U Devaskar
Jun 8, 2012·Environmental Health Perspectives·Kim BoekelheideJohn M Rogers
Nov 10, 2013·Journal of Molecular and Cellular Cardiology·Hugo A GaldamesHans G Richter
Jul 29, 2010·Systems Biology in Reproductive Medicine·Shannon P O'GradyRobert Lane
Apr 22, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Geng TianReinald Fundele
Apr 28, 2004·Trends in Endocrinology and Metabolism : TEM·Peter D Gluckman, Mark A Hanson
May 30, 2006·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Karen L Sweazea, Eldon J Braun
Nov 26, 2016·The Journal of Endocrinology·Valentina PampaniniOlle Söder
Feb 20, 2016·Physiological Reports·Glenn D WadleyMary E Wlodek
Nov 26, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Xingrao KeRobert H Lane
Dec 4, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Qi FuAmber V Majnik
Apr 28, 2018·Clinical Chemistry and Laboratory Medicine : CCLM·Giuseppe Lippi, Gianfranco Cervellin
Aug 31, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Qi FuRobert H Lane
Apr 13, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·E A O'BrienR H Lane
Jul 19, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tho D PhamRobert H Lane
Nov 17, 2017·The Journal of Physiology·Y AsifG D Wadley
Jul 9, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mariana BasergaRobert H Lane

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