Myocardial glucose utilisation in type II diabetes mellitus patients treated with sulphonylurea drugs

European Journal of Nuclear Medicine and Molecular Imaging
Ikuo YokoyamaRyozo Nagai

Abstract

Chronic sulphonylurea treatment maintains improved glycaemic control through mechanisms other than enhancement of insulin secretion and may act on various organs. The aim of this study was to investigate whether the chronic use of sulphonylurea drugs influences PET measurement of myocardial glucose utilisation (MGU) in type II diabetes mellitus. Forty-two patients with type II diabetes mellitus and 17 control subjects underwent dynamic (18)F-FDG PET to measure MGU during hyperinsulinaemic euglycaemic clamping. Twenty-one patients had been taking sulphonylurea drugs for more than 1 year (SU group), and the other 21 patients were drug naive (non-SU group). The haemoglobin A1c levels in the two patient groups were similar. Glucose disposal rate (GDR) was also determined as a marker of whole-body insulin resistance. GDR in the SU group (9.01+/-2.53 mg min(-1) kg(-1)) was significantly higher than that in the non-SU group (4.10+/-2.47, p<0.01) and was similar to that in the controls (9.76+/-2.97). MGU in the SU group (7.66+/-3.02 mg min(-1) 100 g(-1)) was significantly higher than that in the non-SU group (5.53+/-2.05, p<0.01) and was similar to that in the controls (7.49+/-2.74). Chronic sulphonylurea treatment influences MGU indep...Continue Reading

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Citations

Jul 18, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Kooresh I ShoghiMichael J Welch
Feb 22, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Min ZhongBijoy K Kundu
Sep 29, 2009·Journal of Diabetes and Its Complications·Jerzy W Kolaczynski
Sep 8, 2011·Indian Journal of Endocrinology and Metabolism·Vijay Bohra, Velu Nair

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