Myocardial Hemorrhage After Acute Reperfused ST-Segment-Elevation Myocardial Infarction: Relation to Microvascular Obstruction and Prognostic Significance

Circulation. Cardiovascular Imaging
David CarrickColin Berry

Abstract

The success of coronary reperfusion therapy in ST-segment-elevation myocardial infarction (MI) is commonly limited by failure to restore microvascular perfusion. We performed a prospective cohort study in patients with reperfused ST-segment-elevation MI who underwent cardiac magnetic resonance 2 days (n=286) and 6 months (n=228) post MI. A serial imaging time-course study was also performed (n=30 participants; 4 cardiac magnetic resonance scans): 4 to 12 hours, 2 days, 10 days, and 7 months post reperfusion. Myocardial hemorrhage was taken to represent a hypointense infarct core with a T2* value of <20 ms. Microvascular obstruction was assessed with late gadolinium enhancement. Adverse remodeling was defined as an increase in left ventricular end-diastolic volume ≥20% at 6 months. Cardiovascular death or heart failure events post discharge were assessed during follow-up. Two hundred forty-five patients had evaluable T2* data (mean±age, 58 [11] years; 76% men). Myocardial hemorrhage 2 days post MI was associated with clinical characteristics indicative of MI severity and inflammation. Myocardial hemorrhage was a multivariable associate of adverse remodeling (odds ratio [95% confidence interval]: 2.64 [1.07-6.49]; P=0.035). Ten (...Continue Reading

References

Feb 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C S LotanG A Elgavish
Dec 1, 1974·The Journal of Clinical Investigation·R A KlonerR B Jennings
Jan 26, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Peter KellmanAnthony H Aletras
Sep 15, 2007·The New England Journal of Medicine·Derek M Yellon, Derek J Hausenloy
Sep 17, 2009·The International Journal of Cardiovascular Imaging·A M BeekA C van Rossum
Jun 15, 2010·JACC. Cardiovascular Imaging·Charles CannanMatthias Friedrich
Sep 25, 2010·Nature Reviews. Cardiology·W Benjamin Wince, Raymond J Kim
Feb 22, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nilesh R GhugreGraham A Wright
Mar 19, 2011·JACC. Cardiovascular Imaging·David VerhaertSubha V Raman
Dec 17, 2011·JACC. Cardiovascular Imaging·Andreas KumarMatthias G Friedrich
Nov 7, 2012·Journal of the American Heart Association·Alexander R PayneKeith G Oldroyd
Dec 19, 2012·European Heart Journal Cardiovascular Imaging·David Carrick, Colin Berry
Mar 30, 2013·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Ralf WassmuthJeanette Schulz-Menger
Jun 19, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·James W GoldfarbJing Han
Jun 29, 2013·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Ananth KidambiSven Plein
Oct 10, 2013·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Christopher M KramerUNKNOWN Society for Cardiovascular Magnetic Resonance Board of Trustees Task Force on Standardized Protocols
Sep 13, 2014·JACC. Cardiovascular Imaging·Matthijs van KranenburgRobert-Jan van Geuns
Feb 5, 2015·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Christopher M SandinoHui Xue

❮ Previous
Next ❯

Citations

Feb 16, 2017·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Rutger H StoffersWalter R T Witschey
Jun 10, 2017·Journal of the American College of Cardiology·Jacob LønborgUNKNOWN DANAMI-3 Investigators
Mar 11, 2017·JACC. Cardiovascular Imaging·Heerajnarain BulluckDerek J Hausenloy
Jul 22, 2016·European Heart Journal. Acute Cardiovascular Care·Martin ReindlBernhard Metzler
May 10, 2017·Journal of Magnetic Resonance Imaging : JMRI·Elisabeth H M Paiman, Hildo J Lamb
Mar 28, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Xiao-Ming GaoXiao-Jun Du
Mar 16, 2017·World Journal of Cardiology·Jamal N Khan, Gerry P McCann
Mar 1, 2017·Circulation. Cardiovascular Interventions·Heerajnarain BulluckDerek J Hausenloy
Sep 2, 2017·Journal of the American Heart Association·Raquel P AmierRobin Nijveldt
Dec 16, 2017·Circulation. Cardiovascular Imaging·Rohan Dharmakumar
Nov 11, 2017·Circulation. Cardiovascular Imaging·J Ranjit Arnold, Gerry P McCann
Nov 29, 2016·Circulation. Cardiovascular Imaging·Rohan Dharmakumar
Apr 9, 2019·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Colin BerryPeter McCartney
May 28, 2019·European Heart Journal Cardiovascular Imaging·Ahmet DemirkiranRobin Nijveldt
Jul 4, 2019·Circulation Research·Giampaolo NiccoliIngo Eitel
Aug 17, 2019·Cardiovascular Drugs and Therapy·Joseph AllencherrilYochai Birnbaum
Nov 27, 2018·European Heart Journal Cardiovascular Imaging·Peter J McCartney, Colin Berry
Jan 29, 2020·Journal of the American Heart Association·Annette M MaznyczkaColin Berry
Nov 12, 2019·Cardiovascular Research·Lara S F KonijnenbergNiels van Royen
May 16, 2020·Circulation. Cardiovascular Interventions·Annette M MaznyczkaColin Berry
Aug 12, 2020·Journal of Cellular and Molecular Medicine·Hao ZhengYunli Shen
Jun 4, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Henry Gewirtz
Jul 6, 2017·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Nilesh R GhugreGraham A Wright
Aug 31, 2018·European Heart Journal Cardiovascular Imaging·Sebastian J ReinstadlerIngo Eitel

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Clinical Trials Mentioned

NCT02072850
NCT02257294

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SAS
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