Myocardial imaging with extractable cations and inert tracers: the effects of flow and metabolism

Clinical Cardiology
A P SelwynJ P Shillingford

Abstract

The physical and biological properties of 201thallium (Tl) have been investigated and are discussed in this review. A new technique using the ultra-short lived 81mkrypton (81mKr) as a continuous infusion into the aortic root in dogs and man is described. This provides a dynamic assessment of changes in regional myocardial perfusion. Experiments using 201Tl and 81mKr in dogs have shown that regional decreases in myocardial perfusion alone cannot be detected in images of the heart using 201Tl. The effects of perfusion and a variety of factors on the energy dependent cellular uptake of 201Tl are discussed as being of primary importance in changing the regional myocardial distribution of this tracer. The constant infusion of 81mKr in patients with anginal chest pain provides continuous measurement of regional myocardial perfusion in high spatial resolution images. This dynamic method provides a physiological assessment of stenosed coronary arteries at rest and during stress.

References

Jan 1, 1977·Seminars in Nuclear Medicine·H W Strauss, B Pitt
Jul 1, 1977·Progress in Cardiovascular Diseases·S J Adelstein, A Maseri
Jun 1, 1978·Circulation Research·A P SelwynP Lavender
Apr 1, 1976·Seminars in Nuclear Medicine·E Kaplan, L W Mayron
Jul 1, 1977·Progress in Cardiovascular Diseases·T F Budinger, F D Rollo
Sep 1, 1977·Progress in Cardiovascular Diseases·B L Zaret
May 1, 1976·Cardiovascular Research·J H TurnerJ P Lavender
Oct 1, 1976·International Journal of Nuclear Medicine and Biology·A L SwansonE Kaplan
Apr 1, 1975·American Heart Journal·R H SellerC Swartz
Feb 1, 1975·The American Journal of Cardiology·N I LevensonL S August
Oct 1, 1975·The International Journal of Applied Radiation and Isotopes·N S MacDonaldR L Birdsall
Sep 1, 1975·The American Journal of Physiology·R G TancrediJ B Bassingthwaighte
Dec 1, 1973·Circulation·D W RomhiltR A Berke
Jun 1, 1974·Radiology·N D MartinM D Flamm
May 1, 1972·Circulation Research·D G Spiker, C W Smith

Related Concepts

Metazoa
Coronary Circulation
Canis familiaris
Heart
Heart Diseases
Krypton
Radioisotopes
Scintiphotography
Thallium

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.