PMID: 8459084Apr 1, 1993Paper

Myocardial infarct extension during reperfusion after coronary artery occlusion: pathologic evidence

Journal of the American College of Cardiology
A FarbR Virmani

Abstract

The goal of this study was to demonstrate myocardial infarct extension during reperfusion within the same animal. Whether myocardial reperfusion can result in the extension of myocardial necrosis remains controversial. The transformation of reversibly injured myocytes into irreversibly damaged cells after reperfusion has been difficult to demonstrate pathologically. New Zealand White rabbits (Group I, n = 10) were subjected to 30 min of coronary artery occlusion and 180 min of reperfusion. Horseradish peroxidase, a tracer protein that permeates the sarcolemma of irreversibly injured myocytes, was used to quantitate myocyte necrosis at the beginning of reperfusion. Within the same heart, infarct size was measured after 180 min of reperfusion by triphenyltetrazolium chloride (TTC) staining. In separate experiments to demonstrate the validity of the model, rabbits were subjected to 30 min of coronary occlusion, followed by intravenous infusion of horseradish peroxidase and rapid induction of death (Group II) or 30 min of occlusion, 180 min of reperfusion with horseradish peroxidase administered after 180 min of reperfusion and TTC staining after induced death (Group III). In Group I, infarct size at the onset of reperfusion, delin...Continue Reading

References

Aug 1, 1979·Experimental and Molecular Pathology·G RonaM Boutet
Jul 1, 1991·Journal of the American College of Cardiology·F D KolodgieA Farb
Sep 1, 1990·Circulation·T Miura
Apr 1, 1990·Circulation Research·R J SchottW Schaper
Aug 1, 1990·Circulation·G C LiB R Lucchesi
Nov 1, 1989·Journal of Molecular and Cellular Cardiology·C ShiratoJ M Downey
Apr 1, 1988·Journal of the American College of Cardiology·J L RitchieJ W Kennedy
Nov 1, 1987·Journal of Molecular and Cellular Cardiology·J M DowneyD M Yellon
Nov 1, 1985·The Journal of Clinical Investigation·E Braunwald, R A Kloner
Apr 1, 1993·Journal of Molecular and Cellular Cardiology·A FarbR Virmani

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Citations

Oct 31, 1998·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·M Uematsu, M Okada
May 31, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Kai ZacharowskiPeter Petzelbauer
May 1, 1996·Journal of the American College of Cardiology·R C BeckerW J Rogers
Jun 20, 2007·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Khalil FattouchGiovanni Ruvolo
Feb 6, 2003·European Journal of Pharmacology·Jean-Pierre BidouardPhilip Janiak
Aug 19, 2000·Lancet·D M Yellon, G F Baxter
Jan 1, 1996·Pharmacology & Therapeutics·F M Williams
Aug 1, 1997·Journal of the American College of Cardiology·T ShishidoK Miyatake
May 23, 2001·International Immunopharmacology·R NijmeijerC E Hack
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·M BuerkeA M Lefer
Mar 1, 1994·The Journal of Clinical Investigation·M BuerkeA M Lefer
Oct 1, 1994·The Journal of Clinical Investigation·R A GottliebR L Engler
Mar 4, 2008·Biological & Pharmaceutical Bulletin·Guang-Xing BianQiu-Jun Lu
Oct 26, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Pelin KaracaSertac Cicek
Dec 1, 2009·The Journal of Thoracic and Cardiovascular Surgery·Sivakkanan LoganathanGábor Szabó
Aug 28, 2009·IEEE Transactions on Medical Imaging·Jean ProvostElisa E Konofagou
Sep 1, 2004·Journal of the American College of Cardiology·Xi-Ming YangMichael V Cohen
Sep 26, 2006·Biochemical and Biophysical Research Communications·Jinrong FuDongxu Liu
Apr 10, 2016·The Journal of Physiology·John M LawlerJeffrey M Hord
Jun 7, 2013·Thrombosis and Haemostasis·F CarboneF Montecucco
Mar 24, 2004·Microsurgery·Edwin E QuanClaudio Maldonado
Sep 12, 2006·Cardiovascular Drug Reviews·Mervyn B FormanEdwin K Jackson
May 19, 2012·Expert Opinion on Pharmacotherapy·Vikram SharmaDerek M Yellon
Jan 22, 1998·Journal of Cardiovascular Pharmacology·M OmataT Ohno
Oct 12, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M D'AmicoM Perretti
Jun 14, 2000·American Journal of Physiology. Heart and Circulatory Physiology·V H ThouraniJ Vinten-Johansen

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