Myocardial infarct size and mortality depend on the time of day-a large multicenter study

PloS One
Stephane FournierOlivier Muller

Abstract

Different studies have shown circadian variation of ischemic burden among patients with ST-Elevation Myocardial Infarction (STEMI), but with controversial results. The aim of this study was to analyze circadian variation of myocardial infarction size and in-hospital mortality in a large multicenter registry. This retrospective, registry-based study was based on data from AMIS Plus, a large multicenter Swiss registry of patients who suffered myocardial infarction between 1999 and 2013. Peak creatine kinase (CK) was used as a proxy measure for myocardial infarction size. Associations between peak CK, in-hospital mortality, and the time of day at symptom onset were modelled using polynomial-harmonic regression methods. 6,223 STEMI patients were admitted to 82 acute-care hospitals in Switzerland and treated with primary angioplasty within six hours of symptom onset. Only the 24-hour harmonic was significantly associated with peak CK (p = 0.0001). The maximum average peak CK value (2,315 U/L) was for patients with symptom onset at 23:00, whereas the minimum average (2,017 U/L) was for onset at 11:00. The amplitude of variation was 298 U/L. In addition, no correlation was observed between ischemic time and circadian peak CK variation...Continue Reading

References

May 22, 2003·Computer Methods and Programs in Biomedicine·Georg Heinze, Michael Schemper
Jul 11, 2003·Statistics in Medicine·Michael Schemper
Jul 30, 2008·Journal of Biological Rhythms·Christopher M CiarleglioCarl Hirschie Johnson
Mar 6, 2010·Circulation Research·David J Durgan, Martin E Young
Mar 25, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ann W HsingLisa W Chu
Jun 12, 2010·Heart·Dragana Radovanovic, Paul Erne
Jun 24, 2010·Circulation. Cardiovascular Quality and Outcomes·David R HolmesHenry H Ting
Apr 29, 2011·Heart·Aida Suárez-BarrientosBorja Ibanez
Sep 11, 2012·Journal of the American College of Cardiology·Kristian ThygesenDaniel R Wagner
Jan 18, 2013·Clinical Chemistry·Allan S Jaffe, Fred S Apple
Aug 3, 2013·Circulation Research·Stephane FournierOlivier Muller
Dec 1, 2012·Global Heart·Kristian ThygesenHarvey D White

❮ Previous
Next ❯

Citations

Aug 25, 2015·European Journal of Internal Medicine·Stephane Fournier, Olivier Muller
Oct 1, 2015·European Journal of Internal Medicine·Loukianos S RallidisJonh Lekakis
Oct 16, 2015·Extreme Physiology & Medicine·Andrew Murray, Marco Cardinale
Jan 1, 2017·International Journal of Cardiology·Heerajnarain BulluckDerek J Hausenloy
Dec 10, 2017·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Stephane FournierUNKNOWN on behalf on the AMIS Plus Investigators
Sep 1, 2017·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Stephane FournierOlivier Muller
Apr 8, 2018·Journal of the American Heart Association·Carlo Vittorio CannistraciEnrico Ammirati
Jan 26, 2018·European Heart Journal. Cardiovascular Pharmacotherapy·Stephane FournierOlivier Muller
Dec 5, 2015·Clinical Medicine : Journal of the Royal College of Physicians of London·Andras D Nagy, Akhilesh B Reddy
Aug 2, 2019·Emergency Medicine Journal : EMJ·Ziad FaramandSalah S Al-Zaiti
Jan 17, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroshi NakashimaKoji Maemura
Aug 22, 2017·Cellular and Molecular Life Sciences : CMLS·Paishiun Nelson HsiehMukesh Kumar Jain
Nov 7, 2017·Frontiers in Neurology·Sarah L ChellappaChristian Cajochen
Aug 8, 2021·Cells·Søren EgstrandEwa Lewin

❮ Previous
Next ❯

Software Mentioned

Plus
AMIS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.