Myocardial infarction and stroke associated with diuretic based two drug antihypertensive regimens: population based case-control study.

BMJ : British Medical Journal
Inbal Boger-MegiddoBruce M Psaty

Abstract

To examine the association of myocardial infarction and stroke incidence with several commonly used two drug antihypertensive treatment regimens. Design Population based case-control study. Setting Group Health Cooperative, Seattle, WA, USA. Cases (n=353) were aged 30-79 years, had pharmacologically treated hypertension, and were diagnosed with a first fatal or non-fatal myocardial infarction or stroke between 1989 and 2005. Controls (n=952) were a random sample of Group Health members who had pharmacologically treated hypertension. We excluded individuals with heart failure, evidence of coronary heart disease, diabetes, or chronic kidney disease. Exposures One of three common two drug combinations: diuretics plus beta blockers; diuretics plus calcium channel blockers; and diuretics plus angiotensin converting enzyme inhibitors or angiotensin receptor blockers. Myocardial infarction or stroke. Compared with users of diuretics plus beta blockers, users of diuretics plus calcium channel blockers had an increased risk of myocardial infarction (adjusted odds ratio (OR) 1.98, 95% confidence interval 1.37 to 2.87) but not of stroke (OR 1.02, 95% CI 0.63 to 1.64). The risks of myocardial infarction and stroke in users of diuretics plu...Continue Reading

References

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Citations

Oct 28, 2010·Expert Opinion on Pharmacotherapy·Zbigniew Gaciong, Bartosz Symonides
Mar 19, 2011·Journal of the American Society of Hypertension : JASH·Robert D Brook, Alan B Weder
May 15, 2013·Pharmacoepidemiology and Drug Safety·Paul AvillachUNKNOWN l'Association des Centres Régionaux de Pharmacovigilance
May 16, 2020·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Jin WangLingzhong Meng

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Methods Mentioned

BETA
medical procedure

Software Mentioned

ALLHAT
Stata
SAS

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