Myocardial infarction in a newborn heterozygous for the MTHFR C677T mutation

Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
Amy B ClarkDouglas N Carbine

Abstract

Neonatal myocardial infarction secondary to congenital heart disease, anomalous coronary artery anatomy, thromboembolism, coagulopathy, birth asphyxia, and unknown causes has been previously reported. We now report an infant who suffered a massive myocardial infarction during birth, requiring extensive resuscitation and aggressive management. A thrombus, the origin of which was not detected on autopsy, was found occluding the proximal left coronary artery several hours after birth. Genetic studies revealed a single copy variant of the MTHFR C677T mutation that we speculate may have predisposed the infant to coronary thrombosis.

References

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Aug 23, 2001·Archives of Disease in Childhood. Fetal and Neonatal Edition·A TillettJ Simpson
Oct 14, 2005·The New England Journal of Medicine·Seetha ShankaranUNKNOWN National Institute of Child Health and Human Development Neonatal Research Network
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Jan 8, 2011·Pediatric Cardiology·Leanne de VettenBeatrijs Bartelds

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Citations

Jul 13, 2013·Forensic Science, Medicine, and Pathology·Andrew R BamberNeil J Sebire
Feb 8, 2013·Cardiology in the Young·Elio CarusoPaolo Guccione
Jul 3, 2013·Congenital Heart Disease·Marcus-André DeutschChristian Schreiber
Sep 23, 2021·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Elizabeth A ManciRamachandra Bhat

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Methods Mentioned

BETA
cesarean section

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