PMID: 22573751May 11, 2012Paper

Myocardial infarction in patients with familial Mediterranean fever and cardiac lesions

Georgian Medical News
S V Ambartsymian

Abstract

The investigation of relatively rare affections in familial Mediterranean fever--cardiac and lung lesions and pathogenesis of myocardium infarction in background of cardiac lesions is actual. Clinical-morphological analysis of 68 autopsy cases was done. The investigation data observes that cardiac amyloidosis as a dominated morphological manifestation in FMF can leads to heart failure and death. Macroscopically cardiac lesions as a cardiomegaly was observe. The morphological manifestation of cardiac affections in FMF was amyloidosis of the vessels and myocardium stroma. Amyloidosis of the heart valves leads to deformity and clinical-morphological picture of heart defect perform. The large amyloid areas of myocardium leading to the heart insufficiensy according to clinical and instrumental data as pseudoinfarctions were manifested. Myocardium infarction develops in background of cardiac lesions in FMF--amyloid angiopathias, which were more expressed in arteriolar walls, with narrowing or obstructing of lumina, and accompanied with them--coronary vasculitis. The main predisposing pathogenic factors for myocardial infarction can be atherosclerotic changes of the vessels also, which were complicated by amyloid depositions of the va...Continue Reading

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