PMID: 2504141May 1, 1989Paper

Myocardial infarction in rats: effects of metabolic and pharmacologic interventions

Basic Research in Cardiology
H G ZimmerG Marschner

Abstract

Myocardial infarction was induced in rats by ligation of the descending branch of the left coronary artery. The time course of changes in heart function was recorded within the first nine days. There was a progressive decline in LVSP, in LV dP/dtmax and in the pressure-rate-product. LVEDP was elevated. Cardiac output and stroke volume index were depressed after two days. The ATP content in the nonischemic region was lower than control, but recovered spontaneously toward the normal value within the first four days. Three metabolic and pharmacologic interventions known to affect cardiac adenine nucleotide metabolism were applied. Continuous i.v. administration of ribose which stimulates further adenine nucleotide biosynthesis attenuated the fall and promoted the restoration of ATP in the nonischemic myocardium within four days after coronary artery ligation. The elevation of LVEDP was attenuated with ribose after two and four days. The calcium antagonist gallopamil administered as i.v. infusion for two days led to a further reduction of all parameters of left heart function, but did not influence the increase in adenine nucleotide and protein synthesis that occurred in the nonischemic heart. Coenzyme Q10 had only slight effects o...Continue Reading

References

Mar 1, 1975·The American Journal of Physiology·A L ShugJ R Koke
Apr 1, 1986·Journal of the American College of Cardiology·M L SimoonsA van der Laarse
Jul 1, 1987·Journal of Molecular and Cellular Cardiology·H G ZimmerG Marschner
Aug 1, 1971·Journal of Molecular and Cellular Cardiology·S GudbjarnasonP Mathes
Jan 1, 1980·Basic Research in Cardiology·H G ZimmerE Gerlach
Jun 1, 1983·Journal of the American College of Cardiology·S A RubinH J Swan
Sep 1, 1984·Journal of Molecular and Cellular Cardiology·H G Zimmer, H Ibel
Mar 1, 1982·Cardiovascular Research·Y NakamuraK Hara
Jun 16, 1982·European Journal of Pharmacology·J W De JongE Keijzer
Jan 1, 1981·Journal of Molecular and Cellular Cardiology·H OhharaM Nakamura
Jan 1, 1962·The Journal of Clinical Investigation·W L GLEASON, E BRAUNWALD

❮ Previous
Next ❯

Citations

Jun 7, 1995·Molecular and Cellular Biochemistry·H G ZimmerC K Kolbeck-Rühmkorff
Feb 1, 1993·The International Journal of Biochemistry·J A DonohoeJ F Williams
Apr 15, 2004·Medical Hypotheses·Stephen L DoddJohn A St Cyr
Jan 11, 2001·Journal of Cardiovascular Pharmacology and Therapeutics·D F Pauly, C J Pepine

❮ Previous
Next ❯

Related Concepts