PMID: 7361667Apr 1, 1980

Myocardial infarction in the dog: effects of intravenous propranolol

The American Journal of Cardiology
K FoxA P Selwyn


The effects of propranolol on myocardial perfusion and metabolism during acute myocardial infarction were studied in 18 mongrel dogs. A reversible snare was placed on the left anterior descending coronary artery; regional myocardial perfusion was continuously measured using the short-lived isotope krypton-81m, and myocardial metabolism was assessed using the epicardial electrocardiogram and measurement of release of creatine kinase activity from the affected segment of myocardium. Six dogs with no arterial occlusion acted as "sham operated" dogs; six others in which the snare was occluded acted as a control group and a third group of six were given propranolol, 0.5 mg/kg, 30 minutes after coronary occlusion. All variables were recorded before and for 5 hours after coronary occlusion. Dogs treated with propranolol showed a significant improvement in regional myocardial perfusion to the affected segment, decreased loss of electrically active myocardium at the end of each experiment for any given degree of early S-T segment elevation and a delay in the local release of creatine kinase activity compared with that in the control dogs. These results suggest that propranolol exerts a beneficial effect on the progress of ischemic myoca...Continue Reading


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Related Concepts

Diastolic Blood Pressure
Macro-Creatine Kinase
Canis familiaris
Electrocardiographic Recorders
Pulse Rate
Intravenous Injections
Myocardial Infarction

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